| ObjectiveStudy the distribution of IgA nephropathy patients’ TCM syndrome, statistics the dialectical treatment effect of IgA nephropathy and summarize the mentor’s treatment experience, and investigate the correlation between the Oxford pathological classification and IgA nephropathy TCM syndrome, syndrome differentiation and treatment.MethodsRetrospective analysis 80 cases diagnosed as IgA nephropathy by renal biopsy from September 2013 to February 2016 in the clinic of Liu Yuning professor or kidney disease ward (including 55 cases of outpatient treatment). Collecte the TCM four diagnosis, laboratory examination and pathological data of the 80 cases. Their deficiency syndrome can be divided into Qi deficiency, Yin deficiency and Qi andYin deficiency syndrome, and the empirical syndrome can bedivided into damp heat, blood stasis and stagnation of liver qi, toxic heat, micro product and phlegm turbid syndrome. Explore TCM syndrome distribution regularity and the correlation between TCM syndrome and the Oxford pathological classification of IgA nephropathy. To the 55 cases of outpatient treatment, compare and analysis the symptom integral and lab index before and after treatment of traditional Chinese medicine, and assessment the treatment effect. Summarize and analyze 264 pieces of Chinese medicine prescription of 55 cases with frequency statistics. Summarize the mentor’s treatment experience, and investigate the correlation between the Oxford pathological classification and syndrome differentiation and treatment.ResultsIn 80 cases, the deficiency with Qi deficiency syndrome is the most common syndrome in 53 cases (62.90%), secondly to Qi and Yin deficiency syndrome in 23 cases (32.26%), and the least is Yin deficiency syndrome in 4 cases (4.84%); standard empirical with damp heat syndrome of blood stasis syndrome of up to 68 cases (95.16%), followed by stagnation of the liver qi in 59 cases (73.75%), heat toxin syndrome in 47 cases (58.75%), micro volume license in 39 cases (48.75%), and phlegm turbid syndrome is the least in 30 cases (37.5%). 24h urine protein, serum creatinine showe a trend of Yin deficiency< Qi deficiency< Qi and Yin deficiency syndrome. Hypertension incidence rate showed a trend of Qi deficiency< Yin deficiency< Qi and Yin deficiency syndrome. The occurring rate of pathological M1,S1 and Oxford pathological score in different deficiency syndrome exist differences (P< 0.05), and showe a trend of Yin deficiency< Qi deficiency< Qi and Yin deficiency syndrome. Turbid phlegm syndrome and pathological M type exists correlation, and Qi deficiency, Qi and Yin deficiency, phlegm, heat toxin syndrome and micro product and pathological S type exist correlation. Qi deficiency, Qi and Yin deficiency, phlegm, stagnation of the liver qi and micro product and pathological T type exist correlation. After the outpatient treatment, the 55 cases’ TCM symptoms points,24 hours of urinary protein, renal function indicators are improved. Traditional Chinese medicine symptoms markedly improved accounts for 29%, 71% of the total effective.The total effective rate of laboratory indicators is 89.09%, including 8 cases who arecompletely alleviated. Statistics 264 prescriptions, a total of 145 kinds of traditional Chinese medicine. The frequency of The bupleurum, Radix Astragali, Radix Scutellariae, cordate houttuynia, Rhizoma Chuanxiong, Rhizoma Smilacis Glabrae, radix curcumae, Radix cyathulae, Coix Ren is more than two-thirds.ConclusionThe TCM syndrome of IgA nephropathy patients has certain correlation with clinical and pathological factors. The clinical and pathological manifestations in Yin deficiency and Qi deficiency syndrome is lighter, in Qi and Yin deficiency syndrome is heavier. Chinese medicine dialectical combination with pathology in the treatment of IgA nephropathy has good curative effect. The treatment method is mainly yi qi bu xu, shu gan li qi, qing re zao shi, qing re jie du, huo xue hua yu and po xue xiao zheng. |
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