Study On TCM Syndromes Of Invasive Pulmonary Fungal Infection

BackgroundHigh incidence of invasive pulmonary fungal infection, risk factors, wide range of resistance, diagnosis and treatment is often lag, long antifungal treatment, is expensive and side effects, high mortality, an important clinical problem has become a serious threat to human health.Traditional Chinese medicine combined with modern research has found that People’s Republic of China has antifungal activity, strengthen the body’s immune function, etc, in the treatment of IPFI in good curative effect can be obtained. So, further study of the effective methods of diagnosis and treatment of traditional Chinese medicine in the field, positive early intervention and treatment from medical Angle, has important practical significance.Therefore, this research mainly from the onset of IPFI in terms of the characteristics and law of TCM syndrome types of IPFI of TCM syndrome characteristics and the basic pathogenesis of the study, in order to further combine traditional Chinese and western medicine treatment of IPFI provides referential basis.ObjectiveInvestigation of IPFI in patients with general information, medical history, the diseased course, clinical manifestation, knowledge of a risk factor for IPFI and TCM syndrome characteristics, discusses the basic pathogenesis.Method1. Review of IPFI in recent 10 years related literature at home and abroad, experts consultation and feasibility analysis, and combined with the clinical features of IPFI, at the same time, according to the state administration of traditional Chinese medicine in 1994, editor of "standard of diagnosis of disease and curative effect of traditional Chinese medicine" and in 2002, zheng xiaoyu, editor of "Chinese medicine new medicine clinical research guiding principles (try out)", to develop the scale of pulmonary fungal infection of TCM syndrome types.2. With the method of retrospective study, collect in April 2015 to April 2015 the first affiliated hospital of Beijing university of Chinese medicine dongzhimen hospital respiratory oncology department, ICU, CCU, blood in patients with IPFI in hospital of TCM four diagnostic data and other related clinical data, fill in "lung fungal infection of TCM syndrome type questionnaire".3. Related database, set up by using the Excel table will generally clinical cases, medical history, clinical symptoms, TCM syndrome types, such as entry in the database, and check them one by one, in order to ensure the accuracy of the data.4. Use SPSS20.0 package analysis of clinical data, in order to do descriptive statistics analysis, frequency, frequency by Spearman correlation analysis of statistical methods to do correlation analysis between groups, all of the statistical test adopt bilateral inspection, P< 0.05 for relevance, with statistical significance.By chi-square statistics analysis of the differences between groups, P< 0.05 as there are differences, statistically significant.Result1. IPFI condition assessment:IPFI mortality is higher, at about 9.6%.2. IPFI general situation:IPFI happens in the elderly over the age of 75, about 72.2% of the total. Average age was 76, of which the male average age 77, women with an average age of 75 years old.In 104 patients with IPFI male 57.7%, female 42.3%.3. IPFI risk factors:a variety of basic diseases and long-term repeated application of broad-spectrum antibiotics, hormone and immune inhibitor is IPFI important risk factors of the disease.97% of IPFI patients exist basic diseases, of which the cardiovascular system, respiratory system and has a high proportion of the endocrine system, and with high blood pressure, coronary heart disease, cardiac insufficiency, chronic obstructive pulmonary disease, respiratory failure, hypoalbuminemia and diabetes mellitus is the most rare.About 96% of IPFI patients used antibiotics frequently used in more than 20% of the common antibiotics, according to the use of frequency from high to low in turn to e.faecalis or imide southern culture, pp raschig Lin Shu temple, moxifloxacin and levofloxacin, continuous use of antibiotics and more than 6 to 15 days (about 61.6% of the total).19.2% of patients had recently intravenous or oral hormone therapy,3.8% of patients had recently vein or oral immunosuppressive therapy.4. IPFI clinical features:IPFI often with cough, sputum, sputum color white, thick sample or drawing, quantity is little, breathing, chest tightness, dry throat, thirst, shortness of breath lazy words, god fatigue, stay, and poor, insomnia, constipation, urine short red as the main clinical manifestations.Tongue to red tongue, yellow greasy moss, moss little or no moss, the most common.Pulse condition with pulse string, smooth, fine, the most common.And the clinical symptoms have no difference of different gender, age, not statistically significant.5. IPFI TCM syndrome characteristics:IPFI TCM syndrome types in indicates pulmonary syndrome and phlegm heat and Yin deficiency syndrome is the most common.The card type distribution has nothing to do with age, and gender had no significant difference, but there was a significant difference and disease prognosis.Conclusion1. IPFI case fatality rate is higher, happens in the elderly over the age of 75, men more, often with a variety of basic diseases, long-term broad-spectrum antibiotics, hormone and immune inhibitors and other risk factors.2. TCM syndrome characteristics of IPFI:with cough, sputum, sputum color white, thick sample or drawing, quantity is little, breathing, chest tightness, dry throat, thirst, shortness of breath lazy words, god fatigue, stay, and poor, insomnia, constipation, urine short red as the main clinical manifestations.Tongue to red tongue, yellow greasy moss, moss little or no moss, the most common.Pulse condition with pulse string, smooth, fine, the most common.And the clinical symptoms have no difference of different gender, age, not statistically significant.3. IPFI of TCM syndrome types in indicates pulmonary syndrome and phlegm heat and Yin deficiency syndrome is the most common.The card type distribution has nothing to do with age, and gender had no significant difference, but there was a significant difference and disease prognosis.