Clinical Observation On Treatment Of Myasthenia Gravis With Compound Huangqi Granule

Purpose:To evaluate the clinical efficacy of Engelhardtia compound granules. Material and method:60 patients were diagnosed with spleen and kidney two deficiency type of myasthenia gravis, were from March 2014 to March 2015 in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine of patients. At the age of 14-75, 25 cases of male, female 35 cases. The 19 cases of myasthenia gravis patients, 23 cases of patients with IIA type MG, 18 cases of patients with type IIB MG. The duration of 3-48 months. The use of randomly selected patients in 1:1 group, 30 cases were divided into treatment group and control group of 30 cases. The treatment group was given Engelhardtia compound granule + pyridostigmine bromide, the control group was given placebo + pyridostigmine bromide. Treatment for 36 weeks, respectively, 4 weeks, 8 weeks, 12 weeks and 36 weeks observed two groups of patients with clinical absolute scores, total score of Chinese medicine symptom changes and TCM syndrome score changes and observe clinical efficacy of integrated traditional Chinese and Western medicine of two groups of patients.The data statistical analysis software SPSS17.0. Sample comparison of measured data, the normal distribution test, accord with normal distribution were of t test, rank sum test does not meet the normal distribution: count data chi square test, P < 0.05 for differences and is statistically significant. Results:1. Clinical absolute score: into the group and 4 weeks of treatment(4W) between the two groups clinical absolute scores, by t-test, group P value of 0.05, no difference between the two groups; 8W, 12 W, 36 W treatment. In the treatment group, the clinical absolute scores lower than that of the control group, group P value < 0.05, the group has statistical significance, is significantly different. The two groups at different time points, the treatment group from the 4 week, 8 weeks, 12 weeks, 36 weeks and 0 weeks respectively compared with p<0.05, there were significant differences. The control group for 12 weeks, 36 weeks and 0 weeks of p<0.05, there were significant differences.2.(1) two different visit TCM symptom score changes of comparison between the two groups in different visiting time of TCM symptom score at weeks 0 and 4 weeks two group, P > 0.05, no significant difference; treatment 8W, 12 W, 36 W, treatment group total scores of symptoms of TCM is lower than that of the control group, group P value < 0.05, the group has statistical significance. The difference is significant. The two groups at different time points, the treatment group from the 4 week, 8 weeks, 12 weeks, 36 weeks and 0 weeks respectively compared with p<0.05, there were significant differences. The control group for 12 weeks, 36 weeks and 0 weeks of p<0.05, there were significant differences.(2) two different visit principal syndrome score changes: two groups at weeks 0 and 4 weeks in two groups, P > 0.05, no significant difference, 8 weeks, 12 weeks, 36 weeks follow-up period two group comparison of P < 0.05, the two groups have significant difference. The two groups at different time points, the treatment group from the 4 week, 8 weeks, 12 weeks, 36 weeks and 0 weeks when compared to p<0.05, there were significant differences; the control group only in 12 weeks, 36 weeks and 0 weeks when compared to p<0.05, there was statistical significance.3(1) of the western medicine clinical efficacy: recovery: treatment group(n = 0) and(0%) and control group(n = 0)(0%); basic recovery: treatment group(n = 0) and(0%) and control group(n = 0)(0%); effect: treatment group for 11 cases(36.67%), control group in 3 cases(10%). Improvement: treatment group for 15 cases(50%) and the control group in 5 cases(16.67%); invalid: in the treatment group, 4 cases(13.33%), control group for 22 cases(73.33%).(2) clinical curative effect of traditional Chinese medicine: clinical control: treatment group 1 cases(3.33%) and control group(n = 0)(0%); effect: in the treatment group, 9 cases(30%), the control group for 2 cases(6.67%); effective: the treatment group for 16 cases(53.34%), control group, 4 cases(13.33%) invalid: treatment group for 4 cases(13.33%), and the control group 24 cases(80%). Conclusion:Experiments show that Huang Qi compound granule can obviously improve the clinical symptoms of deficiency of spleen and kidney type I and II myasthenia gravis patients, the curative effect is remarkable. Provides a new method of Engelhardtia compound for the prevention and treatment of myasthenia gravis, with further clinical value.