Study On Real-time Monitoring Of Rats’ Brain Edema And Efficacy Assessment

Brain edema following traumatic brain injury (TBI) increases intracranial pressure, impairscerebral perfusion and oxygenation, contributes to additional ischemic injuries and is the main causeof disability and mortality between the ages of1and44years. Real-time monitoring of cerebraledema trends and the use of effective treatment is particularly important.Intracranial Pressure monitoring is an important indicator of cerebral edema. This paper presentsa new intracranial pressure monitoring and draining devices. Use GE P161chip as the sensor ofintracranial pressure monitoring probe, and have drainage effect. When the intracranial pressure is toohigh, it can drain cerebrospinal fluid, reduce intracranial pressure rapidly. The external detectioncircuit uses MSP430as the central processor, responsible for signal processing and output. The LEDcan achieve the function of switching between mmHg, mmH2O, KPa, meeting the need of differentusers. Through debugging the system, the devices can meet the demand for animal experiment,response brain edema timely and accurately.Currently, the dehydrating agent is the first choice for the treatment of cerebral edema. In orderto study the effects of different concentrations and types dehydration on brain edema, we carried outanimal experiment. Rats included in the study were divided into five groups: Group I normal control,Group II trauma control, Group III small does of mannitol(20%,0.25g/Kg), Group IV big does ofmannitol(20%,2g/Kg), and Group V hypertonic Saline(7.5%,10ml/Kg). Made the rat model oftraumatic brain injury and gave different drugs for dehydration treatment. Use ICP and near-infraredtechnology for real-time monitoring. The results show, both mannitol and hypertonic saline canalleviate brain edema, wherein the dehydrating effect of hypertonic saline is better than mannitol andlarge doses of mannitol is better than the small dose. Also shows that reducing scattering coefficienthas a good linear relationship with ICP, can reflect the changes of cerebral edema and can be used asan indicator of cerebral edema, providing reference of using near-infrared spectroscopy in clinicalapplication.