Study On Activation Patterns Of Chinese Writing Function Brain Based On Functional Near-infrared Spectroscopy

Objective: Writing is a key skill for humans to distinguish themselves from other animals.As a skill acquired,the writing process is a complex process that combines various functions,such as visuospatial,motion and sensation.By writing,we are able to transfer the word-shape information through the shape-motion trajectory to the 2D space.In neurosurgery clinical practice,however,when the tumor involving the important functional areas,in order to removal the tumor maximally and safely as well as improve the prognosis of patients,we tend to focus on the patient's language function and motor function,but neglected the function of writing.Although there have been a few studies on the brain mechanism of writing function,there is still no research on the writing function of Chinese characters.This study intends to explore the activation patterns of Chinese characters by functional near-infrared optical imaging.Methods:Recruited 20 right-handed Chinese native speakers with no neurological disease and no language barrier.Detailed description of the purpose and process of the experiment,written informed consent was provided by all subjects before participation.This study was approved by the Ethics Committee of Tianjin Medical University General Hospital.Explore the brain activation patterns of Chinese characters.fNIRS was used to detect the activation patterns of cerebral cortex in 20 subjects,and to explore the differences between Chinese language writing and Latin writing brain activation patterns.It also discussed whether there are differences in activation patterns under different writing tasks(e.g.,stroke number and word frequency).Result:(1)All of the 20 subjects successfully completed the study on the activation mode of the writing function of Chinese characters in the application of fNIRS.(2)Compared with circle task,writing task specificity activation areas including: primary sensory cortex,somatosensory association cortex,primary motor cortex,the supplementary motor area,Broca's area and supramarginal gyrus.(3)Compared with high frequency and low number of strokes Chinese word task,the activated areas specifically involved in task of writing high frequency,low number of strokes Chinese words as well as the words containing a typo character included: somatosensory association cortex,primary motor cortex,pars triangularis Broca's area.Compared with high frequency and low number of strokes Chinese word task,the activated areas specifically involved in task of writing high frequency,high number of strokes Chinese word included: somatosensory association cortex,the primary motor cortex.Compared with high frequency,high number of strokes Chinese word task,the activated areas specifically involved in task of writing low frequency and high number of strokes Chinese word included: the dorsolateral area,the dorsolateral precentral gyrus area,supramarginal gyrus and primary sensory cortex.Conclusion: All of the 20 subjects successfully completed the study on the activation mode of the writing function of Chinese characters in the application of fNIRS.It has confirmed the operability,safety and non-invasiveness of fNIRS.By applying fNIRS to explore Chinese character writing functional activation patterns,the activated areas were primary sensory cortex,somatosensory association cortex,primary motor cortex and the supplementary motor area,the dorsolateral precentral gyrus area,Broca's area,the angular gyrus and supramarginal gyrus.It is consistent with the results obtained from previous studies on fMRI,proving that fNIRS is a highly feasible and credible in exploring writing function.Chinese characters may be stored in the brain in the form of phrases,and the supramarginal gyrus may be related to the word frequency of Chinese characters.We need to verify its correctness through further experiments.