Kinetics And Mechanism Of The Oxidation Of Carboxylic Acids Organic By The Au(Ⅲ) Complex

It is well known that gold is widely used in the treatment of various diseases. With thedevelopment of science and technology, it has been reported that Au(III) and Au(I) complexeshave anti-tumor activity of platinum and be able to avoid the resistance in the treatment withplatinum drugs. Au(III) complexes is more amazing: Au(III) complexes and Pt(II) complexesare isoelectronic and have many properties in common, so it is possible to seek an newanti-cancer drugs to replace cisplatin drugs.Au(III) complexes, however, have a drawback that it is not only likely to be reduced toAu(I) or gold, but also prone to hydrolysis. In order to synthesize the required drugs, Au(III)needs to be further explored and researched, which includes the kinetic and mechanism of theoxidation. The synthesis of Au(III) drug offers the possibility to ensure the stability of theanti-cancer drugs.The kinetics of reduction of tetrabromaurate(III) ion by thiodiglycolic acid, malonic acidand anthranilic acid have been spectrophotometrically studied in acid medium. Under pseudofirst-order conditions ([reductant]o [oxidant]o), the experimental data show that the redoxreaction is first order on [Au(III)] and malonic acid, while a fractional order on thiodiglycolicacid and anthranilic acid. Meanwhile,[H+] inhibits the reaction and the effects of [Br-] aredifferent depending on the reductant. A possible reaction mechanism is proposed and thekinetic equation is derived from the reaction mechanism. It satisfactorily explains all theexperimental phenomena and experimental results.