| Chemiluminescence (CL) methods with high-sensitivity and wide linear range, have beenwidely applied in trace analysis. Especially, the combination of flow injection (FI) technique to CLanalysis can shorten the analysis time and make the process automatic. Quantum dots (QDs),which have unique optical properties, help to improve the sensitivity of CL in some weakchemiluminescence systems and to broaden the linear range of the methods. Therefore, QDs havebeen used as sensitizers to spread the application of CL methods in the fields of environmentalanalysis, pharmaceutical analysis, food analysis, and so on.This paper presents a series of sensitive flow-injection chemiluminescence (FI-CL) methodsfor the determination of theophylline and acetaminophen in pharmaceutical preparations andpentachlorophenol sodium in water/soil samples, by use of the luminol-potassium periodate-NaOHchemiluminescence system with CdTe QDs as a sensitizer. The possible CL mechanism of thesystem is discussed in detail as well. The present work aims to develop FI-CL methods with QDsas sensitizers in the fields of environmental and pharmaceutical analysis.This paper consists of four chapters:chapter1ReviewFirstly, the overview of CL analysis, especially the basic principle and application of luminolchemiluminescence system and prospects of FI-CL methods were summarized; Secondly, the basiccharacteristics, preparation and applications of quantum dots were introduced; Finally, theapplication of different quantum dots in chemiluminescence analysis were reviewed. Totally167references were cited.Chapter2CdTe quantum dots enhanced luminol-potassium periodate chemiluminescencesystem for the determination of theophyllineA novel chemiluminescence(CL)method has been established for the determination oftheophylline based on the ration increasement of theophylline on the CL of the CdTe quantum dots(QDs)-luminol-KIO4system in alkaline medium, in which CdTe QDs showed the strong CLenhancement effect on the luminol-KIO4system in alkaline medium. The CdTe QDs weresynthesized and characterized by transmission electron microscope(TEM), UV-Vis adsorptionspectra and fluorescence spectra.The effects of several factors on CL intensity such as CdTe QDs concentration, luminol concentration, KIO4concentration, NaOH concentration, and flow rate wereinvestigated. Under the optimized conditions, the logarithm value of the CL intensity increasementwas in proportion to the logarithm value of the theophylline concentration in the range from1.0×10-8to1.0×10-5g/mL with a detection limit of2.8×10-9g/mL(3σ).The relative standarddeviation(RSD) of the CL intensity for1.0×10-6g/mL standard theophylline solution was1.14%(n=10). The proposed method has been successfully applied to determine theophylline intheophylline sustained release tablets with the recoveries between98.2%and99.6%. The possibleCL mechanism of luminol-KIO4-theophylline in alkaline medium sensitized by CdTe QDs wasdiscussed in detail.Chapter3CdTe quantum dots enhanced luminol-potassium periodate chemiluminescencesystem for the determination of acetaminophenA novel chemiluminescence(CL)method has been established for the determination ofacetaminophen in the Paracetamol Tablets based on the ration decreasement of acetaminophen onthe CL of the CdTe quantum dots (QDs)-luminol-KIO4system in alkaline medium, in which CdTeQDs showed the strong CL enhancement effect on the luminol-KIO4system in alkaline medium..The effects of several factors on CL intensity such as CdTe QDs concentration, luminolconcentration, KIO4concentration, NaOH concentration, and flow rate were investigated. Underthe optimized conditions, the logarithm value of the CL intensity decreasement was in proportionto the logarithm value of the acetaminophen concentration in the range from1.0×10-7to1.0×10-5g/mL with a detection limit of6.0×10-8g/mL(3σ). The relative standard deviation(RSD) of the CLintensity for7.5×10-7g/mL standard acetaminophen solution was1.33%(n=10). The proposedmethod has been successfully applied to determine acetaminophen in Paracetamol Tablets with therecoveries between97.0%and105.0%.Chapter4CdTe quantum dots enhanced luminol-potassium periodate chemiluminescencesystem for the determination of sodium pentachlorophenateA novel chemiluminescence(CL)method has been established for the determination of sodiumpentachlorophenate(PCP-Na)based on the ration inhibition of PCP-Na on the CL of the CdTequantum dots(QDs)-luminol-KIO4system in alkaline medium, in which CdTe QDs showed thestrong CL enhancement effect on the luminol-KIO4system in alkaline medium.The effects of several factors on CL intensity such as CdTe QDs concentration, luminol concentration, KIO4concentration, NaOH concentration, and flow rate were investigated. Under the optimizedconditions, the CL intensity decreasement was in proportion to the PCP-Na concentration in therange from8.0×10-8to1.0×10-5g/mL with a detection limit of6.5×10-8g/mL(3σ). The relativestandard deviation(RSD) of the CL intensity for1.0×10-6g/mL standard PCP-Na solution was1.08%(n=10). The proposed method has been successfully applied to determine PCP-Na in waterand soil samples with the recoveries between95.5%and103.0%. |
PDF Full Text Request