Phase Behaviors Of Block Copolymer Mixtures

In this paper, we employ self-consistent-field theory and hybrid particle-field theory（SCFT/HPF）to study the phase behaviors of linear triblock copolymer/drugnanoparticle mixtures in dilute solutions into micelles used as drug carriers.Wesimulated Conditions of linear triblock copolymer/drug nanoparticle mixtures indilute solutions into micelles firstly;Then we discussed drug nanoparticleencapsulation efficiency and drug loading capacity in micelles.The specific contentsare as follow:1, This paper employ combined self-consistent-field theory and hybridparticle-field theory（SCFT/HPFT）to simulate the phase behaviors of linear triblockcopolymer/drug nanoparticle mixtures in dilute solutions into micelles used as drugcarriers.we focused the influence of the concentration of the triblock copolymer,Blockratio of the triblock copolymer and the concentration of the drug nanoparticle on drugnanoparticle/triblock copolymer mixtures in dilute solutions into micelles.When theDrug particles volume fraction and Block ratio of the triblock copolymer are fixedvalue, The number of the micelles decrease with the decrease of the copolymerconcentration. the copolymer concentration lower than the critical micelleconcentration (CMC), copolymer can not form micelles. Block ratio of the triblockcopolymer and the concentration of the drug nanoparticle effect the critical micelleconcentration. If block ratio of the triblock copolymer is constant value, The criticalmicelle concentration of copolymer decrease with the increase of the concentration ofthe drug nanoparticle. When the concentration of the drug nanoparticle is constantvalue, The critical micelle concentration of copolymer increase with the decrease ofthe concentration of the drug nanoparticle.2, Self-consistent-field and hybrid particle-field theory（SCFT/HPF） are used tostudy the phase behaviors of linear triblock copolymer/drug nanoparticle mixtures indilute solutions into micelles used as drug carriers.We find that the volume fraction ofthe drug nanoparticles have an important impact on the system of the micellemorphology.When the volume fraction of drug nanoparticles less than the saturated concentration,particulate drug encapsulation rate reached100%and micelle medicinecarrying capacity increases with the drug particle volume fraction increases.But whenthe volume fraction of the drug nanoparticles reach saturation concentration, themicelle drug loading capacity reached the maximum;When the concentration of thedrug nanoparticle is more than saturated concentration,drug particles encapsulatedratio decreased and micelle medicine carrying capacity basically unchanged.When wechange copolymer concentration,we found that the saturation concentration andcopolymer concentration increased linearly relationship.The above results can behelpful for the preparation of copolymer micelle drug carrier in experiments.