The Study Of Phase Behaviors Of Polymeric Micelle Drug Carrier Self-assembly

The nanotechnology used for drug research and development is the importantdirection of modem medical research. Compared with traditional drug, the primaryadvantages of this approach are those, the size of nano-drug is nanoscale lead to easily topermeate through cell to get very good efficacy, has large specific surface area which canconnect with all kinds of functional group, is a good biodegradable material, and has a lotof complex microstructure such as porous、cavity and core shell structure easily to loadand release drug. The influence of the development of nanotechnology is very great ontreating the disease and promotes the development of drug industry. Form2005to2006,20nanomedicine research centers builded by National Institutes of Health carried outlarge-scale system research. Meanwhile the research of the nanotechnology became thehot spot in some developed country such as Japan、Germany and UK. In China, ChineseAcademy of Sciences、colleges and universities also have developed the research.First, the self-consistent field(SCFT) and hybrid particle-field(HPT) are combined toinvestigate the phase behaviors of star triblock copolymer/drug particle mixtures in dilutesolutions and the phase behaviors of diblock copolymer, homopolymer and drug particleself-assembly in dilute solutions. The main content is that, the factors such as theinteraction between each component, the component proportion, volume fraction of drugparticle and volume fraction of homopolymer, influence the phase structure, the micellarsize, micellar shape, drug particle encapsulation efficiency and micelle loading capacity.The more details is as follows:the self-consistent field(SCFT)and hybrid particle-field(HPT) are combined toinvestigate the phase behaviors of star triblock copolymer/drug particle mixtures in dilutesolutions. The phase morphology is influenced by the interaction between each componentand volume fraction of drug particle, and the drug particle encapsulation efficiency andmicelle loading capacity are influenced by volume fraction of drug particle and thecomponent proportion.The self-consistent field(SCFT) and hybrid particle-field(HPT) are combined to investigate the phase behaviors of diblock copolymer, homopolymer and drug particleself-assembly in dilute solutions. The phase morphology is influenced by the volumefraction of drug particle and volume fraction of homopolymer, and the drug particleencapsulation efficiency, micelle loading capacity and micellar size are influenced areinfluenced by volume fraction of homopolymer and the component proportion.