Synthesis And Properties Of Pullulan-based Dendronized Polymers

Functional dendronized polymers have been used for various applications in nano-materials, catalysis research and medicine because of their special molecular structures. In thepast few decades, dendronized polymers have been a hot topic in the research of dendrimer. Inthis paper, we designed series of propargylamine-PAMAM dendrons and acetylenebutylamine-Lys dendrons. And then, these dendrons were conjugated to pullulan via “click”reaction to get dendronized polymers. Details are as follows:（1）Firstly,3-butyn-1-amine was synthesized through “Gabriel” method. And then, aseries of Lys dendrons whose core was3-butyn-1-amine were obtained via divergent growthpathway. The molecular structures of these products were characterized by IR,1H-NMR.（2）A series of propargylamine-PAMAM dendrons with propargylamine core wereprepared via divergent growth pathway. And the G3propargylamine-PAMAM dendrons weremodified by sodium stearate. The molecular structures of these products were characterizedby IR,1H-NMR.（3）Pullulan-Br was obtained when the hydroxyls on the sixth carbon of pullulanpolysaccharides was replaced by the bromine atoms on the NBS. And then the pullulan-N3was synthesized by the reaction between Pullulan-Br and sodium azide. The molecularstructures of the products were characterized by1H-NMR,13C-NMR and elemental analysis．（4）A series of dendronized polymers were obtained by the “click” reaction of thealkynyl of acetylene butylamine-Lys dendrons and propargylamine-PAMAM dendrons andazide group of the pullulan-N3. The molecular structures of these products were characterizedby IR,1H-NMR.（5）Firstly,Linear polymer adamantine-PLA was obtained by the polymerization oflactide initiated by adamantane methanol. and the6-N3-β-CD was prepared from β-cyclodextrin.Then, β-CD-PAMAM was obtained by "click" reaction between6-N3-β-CDand G3propargylamine-PAMAM Dendrons. Supramolecular assemblies with a certainfunction were constructed through the special interaction between adamantane andβ-cyclodextrin derivatives.