Synthesis Of Fluorescent Conjugated Oligomer, Self-assembly And Their Application

Conjugated oligomers have abundant physicochemical property, which are complicatedstructured and easy controlled. Because the nano-materials, which are constituted byconjugated oligomers, have so many advantages, such as, well-shaped surface, easy designedfunction, and applicable using in biological systems that have been paid attention widely andthose also have been used in the fields of electron devices, cell imaging, and testing-sensorsignificantly. About testing-sensor, fluorescence probe technique is one of the hottest researchmethods of this field recently. Fluorescent probe is widely applicable in various fields,including analytical and environmental chemistry, clinical diagnostics, food industry, etc. dueto their simplicity and high sensitivityBased on the above two points we made a kind of fluorescent nanoparticles, there aremainly two parts in the thesis:In the first part of this thesis, based on Sonogashira coupling reaction mechanism,wesynthesizd two kinds of water-soluble conjugated oligomer. The self-assembled oligomer inwater were nanoscale spheres observed by transmission electron microscope.The opticalspectrum and particle morphology of nanospheres were characterized.Cell imagingexperiments showed that the nanospheres have good biological safety,can be absorbedefficiently by the cell and cumulated in the cytoplasm.In the second part of the thesis, by self-assembly method the functional nanoparticleswere successfully perpared.As well the optical spectrum and particle morphology ofnanospheres were characterized. The fluorescent probe of nano-particles can detect quickly.