Synthesis And Characterization Of An Acrylate Pressure Sensitive Adhesive For Transdermal Drug Delivery

Pressure-sensitive adhesives (PSAs) are important and indispensable ones of polymer materials for medical applications. Since PSAs offer the advantages of convenience of use, good stability, simplicity of manufacture and good appearance, PSAs have been utilized in a wide range of medical applications.PSAs play an important role in TDDS, which paste drug delivery system onto skin, regulate drug delivery system as drug carrier, whose composition and performance could impact the TDDS. Thus, the study of structure and performance becomes a critical field in development of TDDS.In this thesis, a copolymer was synthesized by solution method, whose synthesis process was optimized. And the relationship between structure and performance of the copolymer was studied systematically. The methodology of determination of residual monomers was investigated in detail. A precise and efficient technique of determination of residual monomers was established. This work provides the theoretical basis and basic data for the establishment of criterion of PSAs in TDDS. Moreover, it is the theoretical basis of the synthesis and application of acrylic PSAs. The specific work was as follows:(1) In dyadic-copolymer system, the impact of holding time, dropping time, N2/O2, polymerization temperature, type of solvent, type and pouring way of initiator, type and ratio of monomers on reaction rate and polymer characters was discussed. The optimally polymerization conditions were obtained.(2) In tertiary-copolymer system, the adhesive characters and angle of contact of polymer film were measured. The adhesive characters were explored through comparing characters of copolymer with different type and amount of modifiers. It can be found that the elastic modular ratio increased with the rising amount of modifier because of the growing hydrogen bond. The angle of contact reduced owing to the modifier.(3)In pentabasic-copolymer system, the influence of amount of initiator on adhesive characters was investigated. The results show that the amount of initiator between0.4%and0.5%is optimum. The copolymer was characterized by IR,1H-NMR,13C-NMR. The Tg was determined as-43℃by DSC facility. The content of residual monomers of copolymer was measured. The result was as follows:VAc2.98%, BAO.060%,2-EHA0.089%. The prepared copolymer patch containing oxybutynin could release drug smoothly in24h.