Design, Synthesis And Characterization Of Coordination Complexes With L-glutamine And L-asparagine

Natural amino acids are the basic building blocks of living organisms and functionalgroups.Amino acids and their derivatives have unique properties, such as chiralrecognition, selective binding substrate molecules, etc. So they are often used to constructpure chiral organometallic complexes.There are some literatures not only related to thestructures of metal complexes which are built by chiral amino acids and amino acidderivative, but also involving the potential applications in optical, magnetic, adsorptionand so on. Meanwhile, chiral amino acids and metals play a key rolein many lifeprocesses. Therefore, study about the interactions between metal ions and amino acids arehelpful and significant for understanding the role of metal ions in biological systems, andnew drug research and development.In the present paper, we chose L-glutamine and L-asparagine as ligands whichcontaining–NH2,–COOH and-CONH2, so they can provide more coordination sites thanother amino acids. And the lateral chain of glutamine is longer and more flexible, so we canstudy the different structures causing by lateral chain.The paper mainly includes thefollowing three aspects:1. We have synthesized several transition metalions, Cu(II), Zn(II),Cd(II) and Ni(II)coordination complexes with glutamine and analyzed the nature of these complex by themethods of infrared spectroscopy, X-ray powder diffraction analysis, UV-visiblespectroscopy, circular dichroism,thermal gravimetric and other technologies.Interestingly,two of these complexes, the zinc complex Zn(C5H9N2O3)2and the cadmium complexCd(C5H9N2O3)2have been studied by the X-ray single crystal diffraction analysis. Itscrystal structure and chiral property have been investigated.2. The transition metal ions, Cu(II), Zn(II) and Ni(II) coordination complexes withasparagine have been synthesized and characterized by IR spectrum, X-ray powderdiffraction analysis,UV-visible spectroscopy, circular dichroism, thermal gravimetric.Thecrystal structure and chiral property of Ni(C4H7N2O3)2H2O have been investigated.3. The rare metal ions, La(III) coordination complexes with glutamine has beensynthesized and characterized by IR spectrum.Glutamine and asparagine play a key role in many life processes. The research is helpful for further research abou tthe coordination chemistry of amino acids and providesvaluable data as basic gist.