Preparation And Study Of Drug-loaded Textiles Based On PH Polour-changing Indicating The Wound

Halochromism textiles changes colour with the change of pH of external environment, which can be used as a sensor system that can display a visual signal with a non-disrupting system, thus have a great potential market. However, the study of using relatively simple and cost effective technology to endow the textile materials acid photochromic function is very limited. The skin pH changes during healing over a pH ranging from5-6for normal skin and>7in the inflammatory stage. Halochromism textiles could be applied to wound dressing to develop new functional medical textiles that are pH-sensitive, which can tracke the wound healing degree by observing the dressing’s color, thereby avoiding the wound damage to unlock the wound dressing. The skin pH changes during healing over a pH ranging from5-6for normal skin and>7in the inflammatory stage. Halochromism textiles could be used to monitor and evaluate the performance of a skin wound healing recovery system, thereby avoiding the wound damage to unlock the wound dressing.Firstly, a pH-sensor using pH-sensitive dyes and cotton fabric based on standard dyeing process was prepared. Three pH-indicator dyes whose pH discoloration domain near skin were mainly selected for the study, which is Brilliant Yellow, Alizarin and Congo red. The color fastness, halochromism and other properties were studied in detail and we found that three pH-indicator dyes showed good results, a more visible color-change in the pH color domain. Although not all showed good dyeing performance, there is still pronounced color changes, which proved designing a pH-sensor was feasible.Secondly, Two silica gel with improving fastness and drug delivery function were studied, which used tetraethoxysilane (TEOS) as precursor,(γ-glycidyloxypropyl)-trimethoxysilane(GPTMS) as modifier, ethanol as cosolvent, hydrochloric acid as catalyzer. Meanwhile, Ketoprofen (Ketoprofen, KPF) was used as a model drug to study the drug release of the two drug-loaded gel. The test results showed that the morphology of the two gels were regular, chemical stabile, and had a relatively good drug release properties. The analysis of SPM indicates that modified silica film is thinner and more homogeneous than unmodified silica film.Thirdly, drug-delivery textile was fabricated using the two finishing solution above with the method of padding, thus endowed the fabric function of drug-delivery and color-changing. And then further investigates the amount of drug loaded on the fabric, the permeability and tensile properties of the cotton fabric, cell toxicity and drug release in vitro. The test results showed that the slow-release properties of unmodified silica is better than the silica modified. But the changes in the permeability and tensile properties do not affect the cotton fabrics as a normal medical textiles due to both have good biocompatibility.The infrared spectrometer, scanning electron microscope and scanning atomic force microscopy were used to characterize the sol-gel system during the whole process, and at the same time, the amount of loaded drug and its upload rate were determined by ultraviolet spectrophotometer. All of the test showed that the two drug-loaded sol prepared in the experiment have a good performance of drug release in vitro. Although there exist relatively low upload rate and less drug release, the system have met the purpose of the research to a certain extent.