Synthesis And Self-assembly Of Well-defined Stimuli-responsive Block Glycopolymers

Glycopolymers have got increasing attentions for various biologicaland biomedical applications because of their water-solubility andbiocompatibility, meanwhile involving in many biological recognitionevents. Glycopolymer can become as a kind of drug delivery carrier, viaultilizing dynamic covalent binding interactions with boronic acid and1,2(1,3)-diol units in alkaline aqueous solution. And more interestingly theinteractions can be cracked in acid aquous condition. Designing andsynthesizing of glycopolymers with narrow molecular weight distributionis a great challenge for polymer materials. When the property ofstimuli-response is involved in glycopolymers, they will have much moreinteresting properties and wide application. But now, there is not so manypaperswhich are about stimuli-responsive glycopolymers designing,synthesizing and functionalized study.In this paper, we designed and synthesized a series of differenttopological structures and stimuli-responsive block glycopolymers withsame components and different chain composition structures including PGAMA and PDEA and PMEO2MA, respectively. Meanwhile we alsosimply studied thier self-assembly properties and the difference ofself-assembly between different polymer via adjusting PGAMA chainsegment, such as the glycopolymers with different structures and samecomponents. This thesis the whole work content is as follows.1) Synthesis and self-assembly of pH-responsive block glycopolymers: aseries of pH-responsive block glycopolymers, PEG113-b-P(DEA-co-GAMA), PEG113-b-PDEA-b-PGAMA and PEG113-b-PGAMA-b-PDEA, were synthesized via atom transfer radical polymerization(ATRP) by direct or successive polymerization of GAMA and DEAmonomers using PEG-based macroinitiator. Those blockglycopolymers were confirmed by proton Nuclear MagneticResonance (1H NMR) and Gel Permeation Chromatography (GPC),and their self-assembly behaviors were characterized by TransmissionElectron Microscopy (TEM), Dynamic Light Scattering (DLS) andZeta-potential. The results showed that differences of self-assemblyproperties were obtained by these block glycopolymers.2) Synthesis and self-assembly of temperature-responsive blockglycopolymers: a series of temperature-responsive blockglycopolymers, PEG113-b-P(GAMA-co-MEO2MA) and PEG113-b-PGAMA-b-PMEO2MA, were synthesized via ATRP by directpolymerization of GAMA and MEO2MA monomers using PEG-based macroinitiator. Those block glycopolymers were confirmed by1HNMR and GPC, and their self-assembly behaviors were characterizedby TEM and DLS. The LCST were characterized by Uv-visspectrophotometry (Uv-Vis). The results showed that differences ofself-assembly properties were obtained by these block glycopolymers.