Red Fluorescent Silica Nanocapsules:Pluronic^? F127Micelles Template Biomimetic Assembly And Optical Property Studies

Fluorescent silica nanomaterials have significant applications in cellular imaging, biosensing and theranostics. There are several strategies available for the preparation of fluorescent silica nanoparticles, such as Stober method, reverse microemulsion method and sol-gel method. But these traditional wet chemistry synthesis strategies have some drawbacks, including complicated preparation process, large particle size, low biocompatibility and low encapsulation efficiency. Therefore, persuing new methods to facile prepare fluorescent silica nanoparticle with good photostability, high solubility, high sensitivity and favorable biocompatibility is still a big challenge in the fields of materials science and bio-nanotechnology.Herein, we describe a green, convenient and benign strategy to controllable fabricate monodisperse red fluorescent silica nanocapsules via F127micelles template. The growth mechanism and optical properties were studied. Major research results listed as below:(1) Controllable synthesis of F127hybrid silica nanocapsules. The controllable synthesis of F127hybrid silica nanocapsules was studied from F127concentration, TMOS concentration, reaction time and reaction temperature. The results indicated that morphology, structure and dispersity were better controlled by F127concentration, TMOS concentration, reaction time and reaction temperature.(2) The fluorescent properties of F127hybrid fluorescent silica nanocapsules. The results revealed that F127hybrid fluorescent silica nanocapsules had strong fluorescence intensity, and the Nile Red concentration had a great impact on the fluorescent properties of them. Compared with fluorescent micelles, fluorescent silica nanocapsules have stronger hydrophobic cores and lyophobic fluorescent dyes can be better encapsulated by them. All these proved their application as a carrier for lyophobic fluorescent materials. (3) The fluorescence stability of F127hybrid fluorescent silica nanocapsules. The fluorescent properties of fluorescent silica nanocapsules were measured under different time, concentration and temperature. The results manifested that F127hybrid fluorescent silica nanocapsules had better fluorescent stability.