Study On Prepration And Quality Standards Of Liaogewang Dispersible Tablets

OBJECTIVE:liaogewang tablets is an effective resist bacteria anti-inflammation anti-virus on the clinical, it will be improved to dispersible Tablets,which is easy disintegration and absorption, The author has made a systematic study on its preparation and quality standars,METHODS:(1) Study of the preparation:With the rigidity and disintegrant ratio,and parameters of making Granules and Tablets, Optimization of the Liaogewang dispersible Tablets Prescription.(2) Study of quality standars:Preparation the daphnetin by TLC,UV, MS, H-NMR, the C-NMR spectrum analysis determination structure.Liao gewang dispersible Tabletswere identified by TLC.The content of daphnetin was determined by HPLC method. The HPLC was adopted to determine the cumulative dissolution percentage of Liaogewang dispersible tablets.Choose the inspection dissolves the medium, the rotational speed differently, and the time dissolves the situation to the Daphnoretin.RESULTS:(1) the author obtained the optimized prescription:dried powder:microcystalline cellulose:PVPP=220:145:32,3%PVP85% Alcohol (wetting agent),1%microcrystalline cellulose(diluent),0.5%Mag-nesium Stearate gliDants).(2) Thin layer the spot is clear, The separation is good.daphnetin showed a good linear relationship at the range of 0.042～0.252μg (r= 0.9999)The average recovery of Daphnoretin.was 97.08%,while RSD% was 0.71%.daphnetin showed a good linear relationship at the range of 0.021～0.126μg (r=0.9998), The average recovery of Daphnoretin was 96.43% with RSD of 1.94%, Liaogewang dispersible Tablets was determined at 100 r/min,45min,1% polysorbate 80 was adopted as dissolution medium.CONCLUSION:The method is sensitive,accurate and rapid for the quality control of liaogewang dispersible tablets.