The Study On The Preparation And Quality Standard Of Anti-inflammatory Dental Ulcer Filmogen

Anti-stomatitis glycerine (major constituent:Neomycin,Tannic Acid, Vitamin B₁, Vitamin B₂,Hydrocortisone)has been very available medicine to heal to dental ulcer in the clinical application of the Hei long jiang hospital.But it is belong to glycerine cataplasm,it is difficult to being fixed at the ulcer part,so curative effect is confined.Now improving anti-stomatitis glycerine,it is changed to compound membrane,blank membrane is sealing coat which can cover up bad taste and makes medicine membrane release drugs in one-way.Drugs rerich parti affectae,it is that is educing drug action and extending drug action time.Basing on arch-prescripton,Bomeol,Natural Indigo and Pearl powder are added.Heat-clearing and detoxicating,promoting blood flow and removing blood stasis,promoting granulation and alleviating pain,are all added,too.Preparation technology of ant-dental ulcer compound membrane is studied.And quality specification of ant-dental ulcer compound membrane is instituted.Influencing factors and rudiment stability of ant-dental ulcer compound membrane are inspected.The study applies ultraviolet spectrophotometry for test facility,Through inspecting dissolution,PVA17-88 is conducted for film-former of medicine membrane,PVA17-99 is conducted for film-former of blank membrane. The best preparation technology of medicine membrane is definited through the orthogonal experiment.Laurocapram content in the medicine membrane is definited by inspecting accumulation percolation rate.Eight drugs is studied in qualitative investigation by physics and chemistry identification or thin layer chromatography. HPLC is used to the quantitative analysis of Natural Indigo and Hydrocortisone.At the same time, quality specification of ant-dental ulcer compound membrane is established.For therapeutic efficacy in the clinical application, influencing factors and rudiment stability of ant-dental ulcer compound membrane are inspected. Experimental result indicates that in the high temperature condition,content of indirubin depresses at 60℃and does not change at 40℃;Content of hydrocortisone does not depress in the relative humidity 75%±5%. Content of indirubin depresses notablely in the illumination condition. So the praeparatum should be protected from light below 40℃.