Synthesis And Application Of Unilateral Divergent Teg-pamam Dendrimer

Dendrimers have attracted considerable attentions over many research fields such as material sciences and life sciences and so on. The synthetic strategy and molecular structure of dendrimers are both evidently different from most of the traditional macromolecules and greatly affect the chemical and biological properties. The dendirmers are produced by the simple step by step iterative reactions, thus their molecular size, shape and functional group can be designed on the molecular level. Dendrimers are perfectly structured molecules with large numbers of cascade-branched units emerging from a central core, resulting in dense end groups at the molecular surface. A high degree of geometric symmetry, the adjustable cavity, nanoscale size, as well as a large number of surface functional groups could be acquired in a dendrimer's molecular structure. In this thesis, the structure and the characteristics, the synthetic methods, the applications of dendrimer in a number of fields are briefly introduced.In order to obtain flexible structure, we designed, synthesized and characterized triethylene glycol-based dendrimer. The main method is to protect one of the triethylene glycol hydroxyl, and the other side of the hydroxyl transform into amine by a few steps of chemical reaction, thus dendrimer core proceeding through repeated Michael addition reaction and amidation reaction, we finally Synthesise one to five generations with triethylene glycol unilateral nuclear divergence polyamide-amine dendrimer (BnO-TEG-PAMAM). The synthetic dendnrimers was characterized by IR, NMR and other means of product testing. The results showed that the product's structure was basically consistent with the theoretical BnO-TEG-PAMAM.In this thesis, BnO-TEG-PAMAM dendrimer got two aspects of applied research. First, folic acid was grafted at the BnO-TEG-PAMAM dendrimer molecular end so that it has a targeting. And we explore the reaction of ethylenediamine and folic acid in order to find the appropriate line, then a high generation of the G5.0 and folic acid reacted to finally be BnO-TEG-PAMAM-folic acid complex, the product was characterized by UV and NMR. The results show that the folic acid has been successfully grafted onto the dendrimer end. Second, is the BnO-TEG-PAMAM dendrimer as a template to preparation of nano-gold and nano-silver. Work mainly includes various algebraic of ester-terminal and amino-terminal of BnO-TEG-PAMAM dendrimer as a template, in aqueous solution to restore the preparation of Nano-silver particles. With the amino end of the BnO-TEG-PAMAM as a template in the preparation of nanometer gold particles in aqueous solution.The results show that because of this dendrimer structure is too flexible and only some of the high-generation dendrimer can play a template role, derived from nano-solution by UV and DLS detection, indicating that diameter between 10-30 nm.