Spectral Analysis Of Sulfonylureas Hypoglycemic Drugs

The infrared spectrum and Raman spectrum analysis technology have extensive application in the drug testing field. In order to explore the sulfonylureas hypoglycemic drugs’ information, such as their composions, their structures, their solubility and release rate, this paper briefly introduced the sulfonylureas hypoglycemic drugs and solid dispersion. The infrared spectrum, Ramna spectrum and surface enhanced Raman spectrum also been briefly introduced and compared to each other.Through compared the drugs infrared spectroscopy and Raman spectroscopy, we could find that the infrared absorption peaks of gliclazide modified release tablets were been find in 530cm-1, 668cm-1, 880cm-1, 990cm-1, 1161cm-1, 1350cm-1,1443cm-1, 1654cm-1, 1716cm-1, 2392cm-1, 2941cm-1, 3291cm-1, 3492cm-1, while its Raman characteristic peaks were been find in 199cm-1, 282cm-1, 792cm-1, 885cm-1,987cm-1, 1080cm-1, 1162cm-1, 1469cm-1 and 1608cm-1. The infrared absorption peaks of glimepiride tablets were been find in 463cm-1, 561cm-1, 616cm-1, 785cm-1, 881cm-1,1063cm-1, 1258cm-1, 1396cm-1, 1674cm-1, 2105cm-1, 2662cm-1, 2900cm-1,3122~3553cm-1, while its Raman characteristic peaks were been find in 478cm-1、787cm-1, 876cm-1, 1084cm-1, 1330cm-1. The infrared absorption peaks of glipizide controlled release tablets were been find 548cm-1, 840cm-1, 965cm-1, 1104cm-1,1141cm-1, 1661cm-1, 1967cm-1, 2176cm-1, 2370cm-1, 2900cm-1, 3262cm-1, 3330cm-1,while its Raman characteristic peaks were been find in 403cm-1, 517cm-1, 643cm-1,2900cm-1. The infrared absorption peaks of gliquidone tablets were been find 450cm-1,603cm-1, 784cm-1, 895cm-1, 993cm-1, 1187cm-1, 1341cm-1, 1466cm-1, 1661cm-1,2105cm-1, 2913cm-1, 3150~3525cm-1, while its Raman characteristic peaks only were been find in 2917cm-1. The infrared absorption peaks of gliclazide tablets(Ⅱ) were been find in 533cm-1, 673cm-1, 756cm-1, 909cm-1, 993~1174cm-1, 1342cm-1, 1452cm-1,1606cm-1, 1702cm-1, 1925cm-1, 2942cm-1, 3122~3498cm-1, while its Raman characteristic peaks only were been find in 803cm-1, 1160cm-1, 1599cm-1, 2941cm-1,3083cm-1. On the basis of above analysis, we could see that the infrared spectroscopy has a good performance when identify drugs’ groups, while the Raman spectroscopy effect is better in identification no infrared molecular vibration.Comparing the result, we could clearly find that the surface enhanced Raman spectra and its first derivative spectra could increase the Raman single and peaks of the samples obviously, if compared to the traditional Raman spectra. For example, the surface enhanced Raman spectroscopy of glipizide controlled release tablets has characteristic peaks in 1064cm-1, 1262cm-1, 1315cm-1, 1495cm-1, 1625cm-1, compared with the traditional Raman spectroscopy, and the surface enhanced Raman spectroscopy of gliquidone tablets could reveal the molecular structure more distinctly, and increased some peaks in 725cm-1, 1155cm-1, 1246cm-1, 1336cm-1,1398cm-1, 1473cm-1, 1558cm-1, 1640cm-1, 1682cm-1, compared with the traditional Raman spectroscopy. Hence the SERS and its first derivative spectra compared with the conventional Raman spectrum, were more direct, effective and accurate methods,can be more accurately show the drugs’ molecule structure information.In order to increase the solubility and dissolution rate of the five sulfonylureas hypoglycemic drugs, we prepared their solid dispersion and physical mixture. It could be found that their Raman spectra were the same by detecting the drugs’ solid dispersion and physical mixture. This illustrated that the drugs exist with the microcrystal status and form eutectic mixture with the carrier PEG6000. The above results proved that the solid dispersion could increase solubility and dissolution rate of the five drugs.