No Metal Catalysis I₂ Oxidation Synthe- Sis Of Furo[3,2-b]Pyridine Compounds

This paper aims at the studies on the new method for synthesis of 7-methyl-2,5-diphenylf-uro[3,2-b]pyridine with (Z)-3-amino-l-phenylbut-2-en-l-one by no metal catalysis I2 oxidati- on under ambient conditions, Which is divided into three parts as follows:Part one:Developments of the applications of furopyridinesFuropyridines are a well known class of nitrogen heterocyclic compounds that has a pivotal position in the field of drug treatment. Furopyridines are used as HIV protease inhibitors at present. Besides, these compounds also get a very good effect in the field of hypertension treatment, which can also prevent cardiovascular disease.Part two:Developments of the synthesis of furopyridinesGiven the good medicinal value of the furopyridines, simple and efficient methods for the preparation of such compounds are of considerable interest in synthetic organic chemistry. Many of the compounds are developed into clinical drug. According to a large number of literature reports, most of the synthesis method is based on various pyridines ring as a substrate, obtained by cyclizate the desired product.Part three:metal-free catalyst I2 oxidation synthesis of furo[3,2-b]pyridine compoundsWe found a simple, metal-free catalysts method to synthesis of furan [3,2-b]pyridine compounds by study, (Z)-3-amino-l-phenylbut-2-en-l-one was chosen as test substrate to achieve high yield target product. All products were further characterized by 1H NMR,13C NMR, HRMS and single crystal diffractometer. In addition, The synthesis method has extensive application prospect.