Synthesis And Applications Research Of Three Carbazole Derivatives

Chapter 1, Summerize research progress of carbazole derivatives in the aspects of organic optoelectronic materials, fluorescent probes and biological molecular recognition.Chapter 2, A compound with strong electron acceptors and one donator group, named 3,6-(anthraquinone-2-vinyl)-N-ethyl-carbazole, has been synthesized using N-ethyl-carbazole and 2-methyl-anthraquinone. Its photophysical behavior has been studied. We found that the light-emitting behavior of the compound is strongly dependent on the polarity of the solvent. As the solvent polarity increases, the maximum of fluorescence emission spectra shows a significant red shift. In addition, the dipole moment difference △μ, of the ground state and excited state is 3.014D, indicating that a charge transfer occurs from the N atom of carbazolyl to the C=O groups of anthraquinone.Chapter 3,3-(anthraquinone-2-vinyl)-N-ethyl carbazole has been synthesized using N-ethyl-carbazole-3-carbaldehyde and 2-amino-anthraquinone, and its interactions with BSA has been studied using different fluorescence technique. Binging constand are calculated at different temperatures, in addition, the quenching mechanism estimated is dynamic rather than static quenching. Thus we conformed that 3-(anthraquinone-2-vinyl)-N-ethyl-carbazole combines with BSA spontaneously, and the mainly binding force between them is electrostatic force. Non-radiative energy transfer occurred, at the same time.Chapter 4,3,3’-(N,N-diacetic acid methyl amino)-5,5’-di (N-ethyl-carbazole-3-vinyl)-phenolphthalein has been synthesized using cresolphthalein complexing agents together with N-ethyl carbazole-3-formaldehyde. Interaction of this compound with ctDNA has been studied by UV and fluorescence titrations. Fluorescent quenching has been examined using KI as quencher whether DNA presented or not. The combination described is spontaneous, and the binding mode is a mixed-mode of intercalation and groove.