Preparation Of Bagasse Microcrystalline Cellulose And Its Application Performance As Pharmaceutical Excipient

Sugarcane bagasse is the residue of sugarcane after being processed by mechanical expression and extraction. The main components of bagasse are cellulose, hemicellulose and lignin, of which cellulose accounts for about 40%-50%, mostly in crystalline state, and the hemicellulose accounts for about 25%-35%, in a state of amorphous polymers. Others are lignin and small amount of minerals, wax and other compounds. As a kind of plant fiber material, bagasse has great superiority. Currently, Guangxi is the largest sugar producing areas in China, and the annual sugar production accounts for more than 50% of the whole country. According to estimates, about 7,000,000 tons of bagasse is produced every year, and it is the advantage resource in Guangxi.In this study, bagasse was used to prepare microcrystalline cellulose (MCC) that met the medical standards and was used as pharmaceutical excipient, which provides theory foundation for the industrialized application of bagasse solid residue and is the expansion and new choice for the preparation of medicinal MCC. MCC was prepared with bagasse by the processes of dilute alkaline liquor pretreatment, oxidative decoloration, acid hydrolysis and spray drying. The appearance of obtained bagasse MCC was light yellow powder with good fluidity and swelling property. The optimum acid hydrolysis conditions determined by orthogonal experiment are as follows:HC1 solution’s concentration 5.0%, Na2SO3 solution’s concentration 3.0%, hydrolysis temperature at 95℃, and hydrolysis time 60 min. Under these conditions, the yield of MCC reached 73.8% with the content of 99.5%.Ibuprofen orally disintegrating. tablets were prepared by direct powder compressing method using bagasse microcrystalline cellulose as the main filler. The quality of the tablet was evaluated by appearance, disintegration time, dissolution rate and taste. The dosages of different excipients used in prescription were determined by influence factor test with using disintegration time as main index, and other factors such as appearance and hardness were also considered. The optimal prescription is as follows:ibuprofen (main drug) 20%, bagasse MCC (filler) 31%, lactose (filler) 30.5%, cross-linked CMCNa (disintegrant) 8%, pregelatinized starch (binder) 2%, aspartame (sweetener) 2.5%, orange flavour (flavour) 1%, magnesium stearate (lubricant) 2.5%, and micro-powder silica gel (glidant) 2.5%. With this prescription, the disintegration time and dissolution of the tablet met the requirements of the Chinese Pharmacopoeia (2010 Edition).