The Research And Development Of The YIN LAN TONG LUO Soft Capsule

YIN LAN TONG LUO soft capsule main medicinal components compared with YIN LAN TONG LUO oral liquid has no obvious change.In a completely retained the curative effect of oral liquid and completely overcomes the original oral liquid on the packaging, on the palate, the lack of use,it was replaced by YIN LAN TONG LUO soft capsule,which is small doses many, small exquisite packaging, appearance beautiful,convenient carry and save taking.The first part, research the contents in YIN LAN TONG LUO soft capsule: in YIN LAN TONG LUO oral liquid on the basis of extraction and purification process,precipitate the extracted liquid by YIN LAN TONG LUO oral liquid with ethanol,make the concentrated solution to the relative density of 1.45(60 ℃).Measure the flavonoids glycol glycosides,measure the gynostemma saponins and traditional chinese medicine(TCM) fingerprint in the liquid and extractum,show that carries on the enrichment did not affect the active ingredients of the drug. Inspect the honey enrichment process,determine its enrichment of the finish should be selected in the relative density1.42,compare with the commercially available honey,the change of color and fragrance is not obvious,and to maintain a certain liquid.The second part, research YIN LAN TONG LUO soft capsule preparation:equipped with four kinds of soft capsule ratio of excipients, determine the extract: honey: PEG400:PEG6000: glycerin: propylene glycol is 5.37:17.62:19.13:2.31:2.47:0.00,this is the best ratio; configuration ratio of four types of YIN LAN TONG LUO soft capsule capsule shell,the appearance of the no.2-4 is better,these can be used for stability studied.The third part,YIN LAN TONG LUO soft capsule quality standard research:on the original quality standard of YIN LAN TONG LUO oral liquid,it measured quercetin content only,but now increase to the determination of quercetin, galangal, rat Li Su and flavonoids content of glycol glycosides,by measurement,when change after the dosage form,three grain of YIN LAN TONG LUO soft capsule(700 mg/grain)and the activecomponents of YIN LAN TONG LUO oral liquid(10 m L)contains essentially the same,and YIN LAN TONG LUO soft capsules and YIN LAN TONG LUO oral liquid,have reached the quercetin content of glycol glycosides in the original quality standard of not less than 1.10 mg.Increased ultraviolet spectrophotometry method of gynostemma total saponins,known to change after the dosage form gynostemma total saponins basically remain unchanged, and in more than 20 mg.To sum up, through the research of the contents in YIN LAN TONG LUO soft capsule,the research YIN LAN TONG LUO soft capsule preparation and the YIN LAN TONG LUO soft capsule quality standard research,YIN LAN TONG LUO oral liquid after change get YIN LAN TONG LUO soft capsule dosage form, the active ingredient has not changed.