Sound Chemical Preparation Of Grignard Reagents And The Synthesis Of Dimethyl Benzyl Methanol

Dimethylbenzyl carbinol is a kind of important spices, it not only can be used for preparing the fragrant essence of flower, for instance lily, the advanced fragrant essence of flower, the narcissus , the lily of the valley ,etc., but also Dimethylbenzyl carbinol acetate have fresh fragrant and it make it's value double. Dimethylbenzyl carbinol acetate usually used in the fragrant essence of flower of hyacinth, lily, jasmine etc..Grignard reagents are used very extensive in being synthetic in spices, medicine. The traditional preparation craft requests were rigor. Under ultrasonic, the craft of preparation Grignard reagents is simple, reactive time being shorten greatly, only needing simple equipments, mild condition and the reactive impregnant can used ordinary ether or THF that can not need to be dry. Reactive induction period shorten greatly, Grignard reagents of high yield rate can get directly and quite a few Grignard reagents that more difficult to preparation did not need initiator while synthesized under the ultrasonic condition. It has important meanings in industrialization of Grignard reagents.This paper has probed into the synthetic mechanics of Grignard reagents under ultrasonic condition. This paper has studied preparation of Grignard reagents under phonochemistry and optimum technologic conditions is: the power of ultrasonic is 500W and frequency is 250KHZ, having twelve energy conversion devices, water bath temperature being 20C, solvent being THF,unstirred.This paper first prepared Grignard reagent benzylmagnesium chloride under phonochemistry and we have researched the principle and optimum technologic conditions while used benzylmagnesium chloride preparation Dimethylbenzyl carbinol .The optimum technologic conditions is: the concentration of acetone being 12.5 percent, mol ratio being 1.1:1 between acetone and Grignard reagent, temperature being 10C.The main research contents are as follows:1. Discuss mechanism of preparing Grignard reagents under ultrasonic condition.2. Study the technologic conditions of preparing Grignard reagent benzylmagnesium chloride under ultrasonic condition. Explore the new craft of preparing Grignard reagents.3. Study prepared method of dimethylbenzyl carbinol and seek the best technologic conditions and craft route of dimethylbenzyl carbinol.