Benzo Imidazole Salt With The Grignard Reagent Addition - A New Synthesis Method Of Hydrolysis And Ketone

In this paper, the addition-hydrolysis reactions of the benzimidazolium salts, bisbenzimidazolium salts with Grignard reagents were studied. Novel synthetic methods for alkyl methyl ketone, symmetric diketone , long-chain diketone and macrocyclic ketone were provided.Benzimidazolium salt as a new tetrahydrofolate coenzyme model was introduced. If benzimidazolium salt react with nucleophilic reagent, the one-carbon unit at the formic acid oxidation level will be transferred to the nucleophilic reagent, and the biomimetic synthesis to imitate the one-carbon unit transfer reaction of tetrahydrofolate coenzyme will be accompleted. The addition-hydrolysis reaction of 2-substitutied benzimidazolium salts with Grignard reagent was studied and three alkyl methyl ketones, all of which are valuble fragnant substances, were synthesized successfully. A novel method of biomimetric synthesis for alkyl methyl ketones was provided.The addition-hydrolysis reaction of benzimidazolium salt with di-Grignard reagent was reported and a novel synthetic method for symmetric diketone was provided.The addition-hydrolysis reaction of bisbenzimidazolium salt with Grignard reagent was reported and a novel synthetic method for symmetric long-chain diketone was provided.The long-chain diketone described above was applied to the synthesis of macrocyclic ketone and a new method for macrocyclic ketone was reported.The mechanisms of the addition-hydrolysis reacrion and the influence of reaction conditions, stractures on the yield were discussed.