Microwave To Promote The Condensation Reaction Of Carbonyl Compounds

Part I: The organic synthesis under microwave irradiation has been expended to many kinds of reactions, and become one of the hot point for green chemical reaction lately. This work mainly has been carried out around the microwave irradiation.1 An efficient microwave irradiation synthesis of a,a'-bis(substituted) benzylidenecycloalkanones using InCl3 4H2O as a catalyst from cyclopentanone or cyclohexanone with aromatic aldehydes under solvent-free conditions is described. The products were characterized by 1H NMR, IR and elemental analysis, respectively. Moreover, this new procedure is simple, solvent-free reaction condition, environmentally friendly and good yields process.2 Under solvent-free microwave irradiation, a series of 5-arylidene thiobarbituric acid were synthesized by condensation reaction between aromatic aldehydes and thilbarbituric acid. The products were characterized by 1H NMR and IR spectra, respectively. This method is an easy and high-yielding reaction for the synthesis of 5-arylidene thiobarbituric acid derives.Part II: 1H-1,5-benzodiazepine are interesting compounds because of their pharmacological properties and biological activity. 3 kinds of 1H-1,5-benzodiazepine derivatives were synthesized by reaction of o-phenylenediamine and ketones using NiCl2 6H2O or InCl3 4H2O as a catalyst, The title compounds were characterized by 1H NMR, IR spectra.