Studies On The Acylation Under Microwave Irradiation

This thesis consist of three parts:In the first part, the paper summarized microwave irradiation technology increasing extensive application in organic reactions in recent years. The advantage of the microwave irradiation including rate enhancement, easy work up and high yield has also been described in this paper.In the second part, formic acid has been found to be an excellent formylating agent to synthesize 7V-aryl formamides under microwave irradiation in good yields. Compared with the traditional method, the reaction times are shortened 20-120 times. The melt point of the compound is consistent with the literature; the structure of compound is also analyzed by IR.In the third part, arylthiols react with chloropropionic acid to give P-arylthiopropionic acid in good yield under microwave irradiation within short time (3-4min). The p-arylthiopropionic acids obtained in the above procedure are cyclized to give thiochroman-4-ones in the presence of polyphosphoric acid under microwave irradiation. Compared with the classical methods the reaction time is shortened hundreds times, operation is simple and the yield is high.In the fourth part, Aryloxyacetate and arylthioacetate are wildly used in many fields. Various methods have been developed for their synthesis. Some methods have not been entirely satisfactory due to drawbacks such as long reaction time, emerging the problem of corrosivity, effluent pollution, non-recoverable and unavailable catalysts. Silica sulfuric acid carried out at mild conditions with high yield (83-094%). The method is simple, high yields, short reaction times, recyclable and environment-friendly catalyst.