Effervescent Tablet Fuyankang Preparation Process, Quality Standards And Chemical Composition Of Guangdong Callicarpa

Cervicitis is an inflammatory disease caused by germina and it is common infeminine disease. It does not kill the sufferer, however, it often causes a lot ofinconvenience. Badly, cervicitis is one of the causes of matrix cancer. Therefore, thework of making a diagnosis and giving treatment to cervicitids is obviously important. Using with the oral tablet, the effervescent tablet in the paper is hopeful to be anefficient, convenient and easily accepted Chinese traditional preparation.1 Extraction and separation of Callicarpa kwangtungersis Chun. Callicarpa kwangtungensis Chun. is extracted and separated for the first time. 4compounds are isolated with Silica gel, Polyamide, Sephadex gel chromatography and2 compounds are identified with UV, TOF-MS, HNMR, 1 13CNMR spectra. They bothare flavone (apigenin-7-O-β-D-glucopyranside and lutelion-7-O-β-D-glucopyranside).2 Preparation of apigenin-7-O-β-D-glucopyranside The technics of preparation of apigenin-7-O-β-D-glucopyranside is set up with aneasy method. Apigenin-7-O-β-D-glucopyranside is largely prepared.3 Ascertainment of the effective parts of Callicarpa kwangtungersis Chun. The total flavone is ascertained to be the effective part of Callicarpa kwangtungersisChun. It is able to restrain the swell rate of small rat with acute inflammation causedby dimethylbenzenea and chronic inflammation caused by tampon. At the same time, itis able to relieve the pain of small rat with chronic ache caused by venigar.4 Preparation of the effective parts of the effervescent tablet The total flavone of Callicarpa kwangtungersis Chun. and the total alkaloid ofLeonurus japonicus Houtt. is largely prepared. It will be used in experimentation ofpreparation of the effervescent tablet and Pharmacology.5 The quality control of Callicarpa kwangtungersis Chun. and Leonurus japonicusHoutt. and their effective parts The method of determination with HPLC chromatography is set up with evaluationquota of apigenin-7-O-β-D-glucopyranside. Apigenin-7-O-β-D-glucopyranside is0.098% in Callicarpa kwangtungersis Chun. and 4.03 % in the total flavoneaveragely. The method of determination with UV chromatography is set up with evaluationquota of apigenin-7-O-β-D-glucopyranside. The total flavone in the effective parts ofCallicarpa kwangtungersis Chun. is 95.10% averagely and RSD% is 1.10. The method of determination with HPLC chromatography is set up with evaluationquota of Stachydrine. Stachydrine in Leonurus japonicus Houtt. is 0.95% and RSD% is4 妇炎康泡腾片的制剂工艺,质量标准�'�广东紫珠化学成分的研究1.31 and 31.48% in the total alkaloid averagely.The method of determination with UV chromatogram is set up with evaluation quotaof Stachydrine hydrochloride. The total alkaloid in the effective parts of Leonurusjaponicus Houtt is 67.94% averagely and RSD% is 0.40. The method is simple, reliable. It also shows good linear range and stabile resultwhich can be used in quality control of Callicarpa kwangtungersis Chun. Leonurusjaponicus Houtt. and their effective parts.6 Preparation and quality control of the effervescive tabletStudy the effect of excipients on the effervescive tablet with SAS software andsingle factor method and optimize the prescription and technics. The obtainedeffervescive tablet is full, uniformity and polishing. And its quantity of effervescivecomplys with the standard of Pharmacopoeia of the people′ s republic of Chinapublised in 2000. The prescription of effervescent tablet is like follow. the effectiveparts of the effervescive tablet: 20g, tartaric acid: 6g, sodium bicarbonate: 5g,Magnesium stearate: 1%.Apigenin-7-O-β-D-glucopyranside is 18.31 mg and Stachydrine hydrochloride is59.62 mg in every effervescent tablet averagely.