Crown Ether Molecular Recognition Of Adrenaline Electrochemical Characterization And Theoretical Study

As a novel cross subject, supermolecular chemistry based on molecular recognition has been a hot spot of current study. The hydrogen bond is one of the most important intermolecular interactions playing an important role in intermolecular recognition processes essential to most biological systems. Macrocyclic compounds have been extensively used in the chemical analysis of some neurotrasmitters as adrenaline. To study the interaction between crown ethers and adrenaline can propel the development of biology, pharmaceutical chemistry and physical chemistry, etc. In the present thesis, the interaction of hydrogen bond between adrenaline and crown ethers has been investigated by means of electrochemistry and quantum chemistry.Cyclic voltammetry was performed to study the effect of pretreatment of electrode on the cyclic voltammetric properties of adrenaline, which provides the choice of electrodes for the studying of the interaction between crown ethers and adrenaline. The results indicate that the cyclic voltammetric properties of adrenaline is related closely to the electrode and the electrochemical activity of adrenaline is better at electrochemically pretreated platinum and glassy carbon electrodes; all GC electrodes treated by pressing on abrasive powders or polishing with the abrasive papers and powders exhibit good electrocatalytic activity, but the electroactivity of the pretreatment platinum electrodes are poor. The electrode processes of adrenaline at the different pretreatment electrodes are all controlled by the diffused factor.Cyclic voltammetry was performed to study the effect of 15-crown-5 on the cyclic voltammetric properties of adrenaline at different pretreatment GC electrodes and the cyclic voltammetric properties of adrenaline at electrochemically pretreated platinum electrode in a series of acetone solution. The results indicate that crown ethers have stronger stabilization on adrenaline, so...