Tert-octyl Amine Synthesis Of N-tert-octyl Nitramine Mother Ring

The condensation of tert-octyl amine with oxacyclochloropropane or glyoxyal is studied.Tert-octyl amine react with oxacyclochloropropane in hexyl alkyl to synthesis the l-tert-octyl-amidogen-3-chlorine-2-propyl alcohol,then refluence in acetonitrile to synthesis the 1-tert-octyl-3-hydroxyl azetidine's hydrochloric salt.In certain condition,the yeild can reach to 62.7%.HPLC analysis suggest that the purity of the product after re-crystallized in butyl alcohol-acetic ethylic ester solution can reach above 99%.The structure of the product is elucidated by NMR and IR.Tert-octyl amine can react with glyoxya in acetonitvile-water solution to synthesis a new Schiff alkali compound which contain 2 molecule of tert-octyl amine and 1 molecule of glyoxya.The Schiff alkali compound is white solid in room temperature,and it is quite stable.In the condition that is studied, the cyclo-reaction is not occurred.At Iast,the possibility of the 1-tert-octyl-3-hydroxyl azetidine's hydrochloric salt methyl-sulfuric-acyl reaction and nitration reaction is studied.The hydroxyl of 1-tert-octyl-3-hydroxyl azetidine can be replaced by methyl-sulfuric-acyl and nitryl to obtain the l-tert-octyl-3-((methylsulfonyl)oxy)azetidine and1 -tert-octyl-3,3-dinitroazetidine.