Porphyrin Derivatives And Structural Characterization

In this article, the natural cyclic tetrapyrroles and some compounds of this kind were introduced and special attention was given to the application and synthesis of porphyrin and its derivatives, in this base, particular works of the dissertation was put forward.In the course of experiments,first, to compare and evaluated the yield,purity and appronimated costs of two kinds of heme preparation. As compared the two thchniques,method 2 has been proved to be a simple-thchnologied,high-puritied and low-costed technique. This method can be applied in industry production.Deuterohemin was abtained from the reduction of hemin by resorcinol.After being purified by by silicagel column chromatogrophy, pure deuterohem in was obtained. This method is simple and could supply high quaity deuterohemin for the further synthesis.Then,deuterohemin is transferred to deuteroporphrin-IX-dimethylester by the deion-ization and esterification. Compared with conventional reaction, ultrasonic reaction has many advantages such as simpler operation, higher yield and purer product.At last, four kinds of metal-deuteroporphrin-IX-dimethylester are synthesized from deuteroporphrin-IX-dimethylester and metal salt by complexing reactions. At the same time, the study on their optimum experimental conditions of the preparation processes is also carried out. These compounds can be used as bionic catalyst and the intermediate of porphyrin derivatives.The structures of the synthetic products were characterized by infrared(IR),~1H nuclear magnetic resonance(~1HNMR) and mass spectra(MS).The results came to the following conclusions: the structures and performance indexes of the products conformed to the design requirement,the synthesis ways of the target compounds were brief and had high yield.