2 - (2,2,2 - Trifluoroethoxy) Study On The Synthesis Of Aniline

2-(2,2,2-Trifluoroethoxy)aniline, as one of the most important chemical materials, is a main intermediate for agricultural chemicals and many other fine chemicals. 2-(2,2,2-Trifluoroethoxy)aniline was prepared from 2-chloronitrobenzene. The reaction proceeds in two steps. Through the steps such as nucleophilic reaction, filtration, dilution, extraction and vacuum distillation, the 2-(2,2,2-trifluoroethoxy)nitrobenzene is separated from crude product. Then 2-(2,2,2-trifluoroethoxy)nitrobenzene was hydrogenated by catalyst, the target product was got.This dissertation made a research on the following factors such as reaction temperature, time, catalyst and dosage of all kinds of materials. After the dissertation introduce single factor to consummate the technological process and technological condition, the optimal process parameters for synthesizing 2-(2,2,2-trifluoroethoxy)aniline. The product was determined by the ways of qualitative analysis such as NMR, MS, IR. The content of the product is 97.5% by the HPLC. Through the research of influencing factors, the optimized technology was as follows: for the first step, N,N-dimethylacetamide as solvent, n(2-chloronitrobenzene):n (so dium trifluoroethanol):n(cuprous iodide)=1:2:2,temperature 140℃,time 5h.The yield of 2-(2,2,2-trifluoroethoxy)nitrobenzene can be reached 87%. For the second step, ethanol as solvent, catalyst Pd/C, temperature 75 ℃,time 1h,the yield of 2-(2,2,2-trifluoroethoxy)aniline can be reached 97%.Moreover,the gross yield is up to 82%.