Amoxicillin (ampicillin), Process Improvement,

The penicillin's discovery is a milestone of medical development in the 20^th century. Disease which was deadly in the past, can be cured effectively by the penicillin. It has been healing millions' of people.In the semi-synthetic penicillin's market ,there are ampicillin,amoxicillin, mezlocillin,azlocillin, cloxacillin,piperacillin, which have definite shares in the penicillin's market. As a result of amoxicillin can be absorbed effectively by mouth, output and sale increase with steady steps in the global. By 20 year's clinical adhibition, amoxicillin has been a popular kind in the prescription drugs. The thesis discuss synthetic technics of amoxicillin,ampicillin,mezlocillin and azlocillin, which can increase the production and the rate.Optimized manufactural technics, through alter reaction time and reaction temperature,is discussed in this thesis. Replacing the 2,6-dimethylpyridine with the pyridine , can raise the productivity, and lower the operating costs. We develop new products: mezlocillin and azlocillin,which contribute strength for the economic performance of the company.