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Applied Research, Supercritical Fluid Extraction Of Natural Products

Posted on:2008-01-14Degree:MasterType:Thesis
Country:ChinaCandidate:Q ChangFull Text:PDF
GTID:2191360215465166Subject:Supercritical fluid technology
Abstract/Summary:PDF Full Text Request
In this thesis, the theory, features, history and present advancement of supercritical fluid technology are introduced with the physical and chemical properties of carbon dioxide. The advantages of carbon dioxide used as an extracting solvent are also discussed.The supercritical fluid extraction technology applied to lecithin, gingko, safflower seed and herbal medicines such as caucuma longa and aucklandia were studied in this thesis. The preparation methods of raw materials and consequent effects in the experiments were discussed. In the extraction experiment of lecithin, the granulation methods of raw material were tested and discussed, so that the appropriate granule density was determined. Particular sieving are also performed according to the granularity after the other raw materials were crushed.Orthogonal experiments were also adopted, in which extracting yields was the target and pressure, temperature and flowing rate were studied. The effects of these elements upon the extraction were discussed and the appropriate process condition were determined.Common physical and chemical tests were conducted upon the extracted products. Furthermore, particular ingredient analysis was performed via liquid chromatography and gas chromatography / mass spectrometry. Considering the medicine and tonic application of products, heavy metals contents and microbial limit were also tested.On the basis of the lab process result, industrial scale-up of the lecithin extraction process was performed. The problems presented arisen during the scale-up were handled and satisfying results was attained.In the above natural products, the SFE of neither gingko nor safflower seed has been found reported. In the ingredient analysis of aucklandia, an effective ingredient has been detected which had never been reported in other SFE research.
Keywords/Search Tags:supercritical CO2 extraction, lecithin, gingko, safflower seed, caucuma longa, aucklandia, GC/MS, industrial scale-up
PDF Full Text Request
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