Pharmaceutical Fluidized Bed Numerical Simulation

Fluidization is the technology that is used in Chemical Industry, Energy, Metallurgy and many other area .In chemical industry, it is wide used for reinforcement heat and mass transfer, gas-solid reaction, physical refining, even granule produce and deliver.The fluidized-bed pelletization packaging for pharmaceutical factory mostly depended on non-uniform distributing pore plate. Especially, the center of distributing plate region have a high orifice coefficient, it blows medicine granule up and come into fluidization. On this condition, medicine granule be clothing and drying layer by layer, finally the whole process is completed.The fluidized-bed pelletization packaging machine has been introduced by Shanghai MEI YOU Pharmaceutical Ltd. This machine should be redesigned, reconstructed, installed and adjusted. The design of ventilation system and heat source selection, the control of temperature and humidity are summarized. The conclusion indicates that fluidization air rate, temperature, humidity, the property of compressed air, bond content and other factors influence on packaging. Aim at two kind of cone distributing plate which has different holes distributing form. It is marked as new and old cone distributing plate. By numerical simulation, we can reach conclusions that new cone distributing is better than old one in this system. From numerical simulation, a structure improvement is given for cone distributing plate. Another kind of distributing plate——flat distributing plate, is also discussed and simulated.The three-dimensional numerical simulation is used to prove the influence of air inlet position on air-flow organization of inner fluidized-bed. This study summarized a method that substitute porous media and ring structure for real distributing plate by numerical simulation. Because the suitable model and the relation of air rate-pressure drop are hard to find in ring structure model, the porous media is used. Also, inertial resistance factor and permeability factor which is important factors for porous media, is acquired by numerical simulation.From numerical simulation, we know that Euler model and the interphase exchange model based on Gidaspow'theory is suitable to qualitative analysis of numerical simulation of pharmaceutical factory fluidized-bed and similar dense-dilute-coexist systems.