Nmr Studies Of Beta-cyclodextrin With Benzimidazole And Naphthalene Derivatives Interaction The Mangosteen Flavonoids And Danshensu Of Compound Structure

Supramolecular chemistry is one of the new branches of the chemistry,it has been regarded as one of the important headstream of new conception and advanced technique.Supramolecular chemistry is the foreword of modern chemistry.β-Cyclodextrin is regard as a kind of important supramolecular system,which is the most important host compound,the most useful with respect to the other compounds of recognition and assembly.Benzimidazole and their derivatives are important material and intermediate product,it is a important structure cell which consist in many medicines.NMR is one of the powerful methods use to study the supramolecular chemistry,it is no damage,convenience and offer abundant data,so it was widely used to the supramolecular chemistry.We study the recognition betweenβ-Cyclodextrin and Benzimidazole derivatives by NMR method.We find out their action form and the stability constant of inclusion complex.These investigation find out a new method for synthesization.The development and application of supramolecular chemistry and NMR were reviewed.Based on that,several benzimidazole derivatives were synthesized from o-phenylenediamine.The spatial structures and supramolecular systems that formed byβ-CD with seven guest compounds,1,3-dimethyl-2-cyclopropyl benzoimidazolium salt,2-methyl benzimidazole,1,2-diethyl benzoimidazolium salt,2-phenyl-benzimi-dazole,1,3-dimethyl-2-cyclohexyl benzoimidazolium salt,β- naphthol,1-amino-8-napthol-3,6-disulfonic acid sodium salt,were studied by NMR.In addition,the ascription and spatial structure ofα-mangostin and effect of the different substituted groups of tanshinol derivatives were investigated by ¹H,¹³C, COSY,ROESY,HMBC.