1,3 - Dicarbonyl Compounds Direct Alkylation Green Studies On The Synthesis Of Solid Phase

A highly efficient CeCl₃·7H₂O-NaI-catalyzed alkylation of various 1,3-dicarbonyl compounds with various allylic alcohols under solvent-free condition has been developed. The procedure proceeds well with good yields at 50℃using SiO₂-supported CeCl₃·7H₂O-NaI system as the catalyst and represents a simple and convenient methodology for the preparation of densely functionalized molecules. And the SiO₂ -supported CeCl₃·7H₂O-NaI as the highly efficient Lewis acid catalyst can be reused for several times here to obtain high yields.The synthetic process of alkylation of various 1,3-dicarbonyl compounds with various allylic alcohols was researched. The reaction parameters such as solvent, reaction temperature, the ratio of reaction substrates and catalyst and reaction time were optimized, products were obtained. 'H-NMR and MS of the products were obtained.The effect of repeated use of promoter to the eaction between 4-Phenyl-but-3-en-2-ol andβ-diketones was investigated.¹H-NMR and MS of the products were obtained.