Study On Asymmetric α - Allylation Of Palladium (0) Catalyzed Thiouramide And Strategy For Solvent - Free Synthesis Of Thioester Compounds

Thioamides are a class of important compounds with wide applications inorganic and medicinal chemistry. They have S, N and a-carbon three nucleophiliccenters and have been extensively used to build vaired heterocyclic compound viareaction with electrophiles. Compared to structure-related amides,thioamides havedifferent electronic properties and they are rarely used as carbon nuclcophiles fortransition-metal-catalyzed coupling reactions.In this master thesis, we focused onasymmetric Pd-catalyzcd allylic allylation of thioamides, to give a variety of chiralthioamides in moderate to good yields with good enantioselectivity. The workincludes the following parts:1.The synthesis of starting materials via Lawesson reaction.2.Development of asymmetric Pd-catalyzed allylic allylation of thioamides.3.Solvent-free synthesis of thioestors from corresponding estors.