Capecitabine His Guests Synthesis Process

The current situation of cancer and the classification of anticancer agents were briefly introduced in this thesis.The present development of Capecitabine was particularly introduced.After analyzing the 4 reported routes,two of them were chosen to study further,and then identified the best one.After got through 3 reported synthetic routes to obtain Capecitabine,an unreported route was designed and finished.Based on these four routes,finally the most economical one was picked up.5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranoside(9)was obtained from D-ribofura -noside through 6 steps like acetalation protection,paratoluensulfonylation,bromation,reduction, deprotection and acetylation.The structure of Capecitabine and 5-deoxy-1,2,3-tri-O-acetyl-D-ribo -furanoside had been confirmed by MS and ~1H-NMR.The mechanism of Silyl reaction had also been discussed in this thesis.