| Block copolymers have rich phase behavior,and in the bulk they can microphase separate to form spheral,cylindrical,bi-continuous or layered structure.Block eopolymers as important macromolecular material were widely applied in pharmaceutical field.The applications as hydrogels,microspheres,nanospheres in drug delivery system and biodegradability and biocompatibility of block copolymers were researched.It is well known that amphiphilic diblock copolymer,the hydrophobic chain and the hydrophilic chain are connected together by the chemical bonds,when it is dissolved in the solution,their synergistic effect,showing the rich self-assembly behavior.Amphiphilic diblock copolymer,like small molecular surfantants,lipid amphiphilic molecular in selective solutions can self-assembled to all kinds of aggregates.The morphologies include microspheres,nanutube, wormlike,cylindrical,vesicles,and lamellar,its size from nano- to micron- level even greater. As a result,what's more,block copolymers with predetermined structure and series could be easily synthesized.And living radical copolymerization is one of the mostly actively study fields in macromoleeules science at present.Recently considerable attentions have been paid to the study on the living eopolymerization.Atom transfer radical copolymerization(ATRP) is the ideal method to carry out the living copolymerization.Based on such a background,the block copolymer PMMA-b-PAA and PMMA-b-PAM were synthesized by ATRP technology in this paper.Specific studies are summarized below.The synthesis of PMMA-b-PAA has been achieved successfully by ATRP method in anisole solvent at 90℃,using prepared CuCl as catalyst,ethyl 2-bromopropionte as initiator. The block copolymer structure was confirmed by FT-IR and ~1H NMR.Finally,it is possible to synthesize PMMA-b-PAM and PMMA-b-PG using repared CuCl as catalyst,PMMA-Br as maeromolecule initiator.The block copolymer structure was confirmed by FT-IR and ~1H NMR. |
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