Potassium Ferrocyanide As An Environmentally Friendly Cyanide Reagent Cyanation

Green chemistry was also been called envionment-benign chemistry, envionment-innocuous, cleanning chemistry, decreaseing and eliminating the protuction- application of poison by zhe chemistry techonology method. Recently, the reasearch of the synthesize of green chemistry were abstract more and more attention. Cyanide reaction was also abstract a lot attention in the lastest years, but at present time, there is a large space for improving solvent, catalyst, and cyanide reagent. For this paper, we mostly research for the common cyanide reaction with potassium hexacyanoferrate as envionment-benign cyanide reagent,otherwise the paper start with the viewpoint of the green chemistry, investigate the common cyanide solvent, common cyanide catalysts either for some reactions, we predigest some solvents and catalysts,making the reaction more feasible.Chapter I: Introduce some knowledge about green chemistry, In succession, review the basic information and the development course of the cyanide reaction, Then introduce the common solvents and catalysts which is used in the cyanide reactions.Chapter II:Investigate the substituent reaction of Potassium hexacyanoferrate as envionment-benign cyanide reagent with aroyl chlorides. We improve the reactions which use the cyanide group substituent the halogen atom of the acyl halogen and the aryl halogen. And then we ameliorate the catalysts and the solvents, thus there is a new methods to the substituent reaction: solvent-free method.Chapter III:Research the addition reaction of potassium hexacyanoferrate with carbonyl compounds directly. We use potassium hexacyanoferrate as the addition cyanide reagent firsthand, which was no report in the literature before. Then we explore many conditions about the reaction, and gain many conclusion, and the more, we obtain many important conclusion,which is the foundation to the latter reactions. Chapter IV: Use the aroma carbonyl compounds replace the alkyl carbonyl compounds, continue use the potassium hexacyanoferrate as the addition cyanide reagent, introduce the cyanide group into the production.In total, Potassium hexacyanoferrate as a envionment-benign cyanide sources is more and more meaningful. There is a lot of deficiency in my experiment, I should make more efforts in the latter work.