Gel Synthesis Of Small Molecule Drug Carrier

The range of hydrogel related is more and more broad in the field of medicine, but most of which is still in the stage of research, and is not broadly used in product exploitation. Most of the researchers only pay attention to the field of application, and the research of the theoretical investigation is wished to be more deep. The research of hydrogel in our country started a little later, most of which focus on drug controlled release carrier, cornea contact glass material, tissue filling material etc. Hydrogel is a kind of novel functionalized macromolecule material, which has a three-dimensional meshwork structure and is widely used and researched because of its advantages like high moisture content, quick swelling, pliability, mucosity as rubber, good biocompatibility. Hydrogel is more like living tissues than any other synthetic biology material, which could reduce the attrition and mechanical action with surrounding tissue after swelling.Hydrogel material similar to dead tissue, cell and protein adhesion capacity is weak, with blood, body fluids and human tissue when in contact, showing good biocompatibility, it will not affect the body's metabolic processes of life, metabolites can also discharged through the hydrogel.In drug delivery, the active drug component simply filling in the gel network or adsorbed in the gel network in order to achieve sustained release agents。In this paper, designed and synthesized 4-hydroxy mandelic acid connected to the acid as drug carrier, hydrophilic part of the order of 2-(2-aminoethoxy)-ethanol as the starting material, connected to a bromine acid molecule with exposed carboxyl groups after allyl to protect the hydrophilic part; intermediate connection part is 5 nitro-isophthalic acid as the starting material, through the reduction of nitro after allyl protection of carboxy-after for the amino and 4-hydroxy mandelic acid connected to the penicillin-sensitive phenyl carboxylic acid and drug molecules connected through the condensation reaction, And then connect some of the carboxyl protecting group is removed and the hydrophilic carboxyl group exposed part of the amino reaction by condensation, so that part of the benzene ring connected to form three amide bond; and then remove the hydrophilic part of the protecting group after the final The target compounds, the final target compounds by 1HNMR structures were characterized.