| Hydrogel materials play an indispensable role in many fields due to their unique mechanical flexibility,biocompatibility and many unique properties similar to those of organic organisms.However,the development and application of traditional hydrogel materials are constrained to some extent by the excessive use of fossil raw materials,complicated preparation methods,poor functionality and difficulty in reuse.Therefore,the development of multifunctional hydrogel materials with simple preparation process,environmentally friendly and reusable has become one of the research hotspots in the frontier of polymer materials.In this thesis,an interpenetrating cross-linked network hydrogel(EDA-CD-HEC)based on hydrogen bonding was prepared by using hydroxyethyl cellulose(HEC)with good biocompatibility as a hydrogel matrix and ethylenediamine-modified β-cyclodextrin(EDA-CD)as a cross-linking agent.In order to solve the problems of short half-life,frequent administration,high side effects and low bioavailability of oral hydrophobic drugs,EDA-CD-HEC hydrogels were used as carriers of hydrophobic drugs,and ibuprofen(IBU)with low bioavailability was selected as a model drug to investigate the ability of EDA-CD-HEC hydrogels to recognize,piggyback and slow release IBU.In order to solve the problem that patch-type hydrophobic drugs are difficult to be uniformly dispersed in hydrophilic matrices,menthol,which is both lipophilic and irritant,was selected as a model drug to evaluate the development prospects of EDA-CD-HEC hydrogels in the field of wound dressings.(1)β-cyclodextrin(β-CD)was chemically modified using ethylenediamine(EDA),and the solubility of the modified EDA-CD was 12.84 times that of β-CD.By changing the molecular weight of HEC and the ratio of HEC/EDA-CD,the EDA-CD-HEC hydrogel was prepared rapidly within 0.6 min with good mechanical properties,swelling properties and chemical stability.(2)The ability of EDA-CD-HEC hydrogels to recognize,piggyback and slow release IBU was investigated using ibuprofen selected as a model drug with low bioavailability.eDA-CD has the molecular recognition ability of the chiral drug-S-(+)/R-(-)-IBU,and can form stable inclusion complexes with S-(+)-IBU and increase its solubility increased by 1113.38 times.The amount of IBU carried in EDA-CD-HEC hydrogels was determined by chemometric analysis using instrumental means,and the release mechanism of IBU in IBU/EDA-CD-HEC hydrogels released in vitro was investigated by four kinetic models.The environmental friendliness and biocompatibility of the IBU/EDA-CD-HEC hydrogel drug delivery system was demonstrated by in vitro degradation experiments.(3)The potential of EDA-CD-HEC hydrogels for wound dressing applications was verified using menthol,which is both lipophilic and irritant,as a model drug.EDA-CD was able to bind to menthol to generate stable inclusion complexes and to disperse menthol uniformly in the hydrogels.The menthol/EDA-CD-HEC hydrogel was shown to slow down the volatilization and release of menthol by means of chemometric analysis using instrumental analysis at a rate approximately 0.1 times that of the physical mixture of menthol and EDA-CD.The menthol/EDA-CD-HEC hydrogel not only has self-healing properties,proper swelling properties and good reusability properties,but also has a certain degree of antibacterial properties and good biosafety,which have promising applications in the field of wound dressings. |
