The Copper-catalyzed C-n Coupling Reaction And The Reaction Of C = N,

With development of economical, the traditional chemical industry lead to increasingly serious pollution of the environment, the conflict of human and environment is in the continuous intensification. Environmental problems have threatened the survival of the human environment, and are a threat to the development of human beings, which are reasons that why the green chemical industry is the main direction of chemical industry of the world. C-N cross-coupling reaction is an important content of organic chemistry, and medicine in chemical widely used in both. The traditional reactions have generally required specific catalysts and harsh conditions, there has limitations for both industrial and economic operation. Aromatic polyimide compounds are very important pharmaceutical intermediate synthesis, In industrial synthesis, the most commonly used method is the use of primary amines and aldehydes, alkones or alcohols by dehydration condensation reaction to imines.The focus of this thesis are synthesis imines through C-N cross-coupling reaction and C=N reactions catalyzed by efficient solid catalysts. Copper oxide and cuprous oxide are cheap, low toxicity and solid catalysts. So using copper oxide and cuprous oxide as catalyst is in line with the requirements of the chemical industry green.The main contents of this thesis:1,Using different morphologies of cuprous oxide as catalysts was in the iodine benzene and benzylamines of C-N cross-coupling reaction, and we want to obtain a different catalytic activity of the different crystals faces of cuprous oxide. But low response rate can not be as evaluation standards for the unit catalytic performance. But the studies provided the foundation for the research in the future.2,CuO/acidic Al2O3 as catalyst, toluene as solvent, oxygen atmosphere, temperature 110℃, 24h reaction as conditions of reaction, coupling reaction of benzyl amine and its derivatives through transmaination-coupling reactions and dehydrogenation-oxidation of aromatic amine were to synthesize imine. We had a good response and a high rate of productions, and durability for primary amines.