Study On Assessment Of The Left Ventricular Function Using Dual-source Ct

Objective: (1) To evaluate left ventricular (LV) function using the data sets reconstructed every 2%, 5% and 10% (0-100%) of the R-R interval. (2) To explore the accuracy and feasibility of Dual-source CT (DSCT) in evaluating the left ventricular function through comparing left ventricular volume data obtained by DSCT with data gained by echocardiography.Methods: (1) Twenty-four healthy adults (18 males, 6 females) and twenty-six patients (21 males, 5 females) with known coronary artery disease (CAD) referred to our department for noninvasive dual-source CT coronary angiography (DSCTA) were included in this study. To evaluate LV function, slices were reconstructed in the review, starting at 0% to 100% of cardiac cycle in various interval of 2%, 5% and 10%, respectively. End-diastolic phase was defined as the largest left-ventricular volume and end-systolic phase was defined as the smallest left-ventricular volume. Using the workstation's'cardiac function analysis tool, LV end-diastolic volume (LVEDV) and LV end-systolic volume (LVESV) were determined and the LV ejection fraction (LVEF) was derived. All variables were expressed as mean values and standard deviation. A p-value of below 0.05 was considered statistically significant. (2) Thirty-one patients with known or suspected coronary artery disease (CAD) referred for evaluation of coronary angiography using DSCT also underwent echocardiography within 48h. The left ventricular function which include left ventricular end systolic volume(LVESV), left ventricular end diastolic volume(LVEDV) and left ventricular ejection fraction (LVEF)were determined using the two modalities. Statistical analysis included Pearson correlation coefficient.Results: (1) No significant differences were found when comparing the reconstructions among the measurements of every 2%, 5% and 10% of the R-R interval(.In the healthy adults group, the p values of ESV, EDV, SV, EF were 0.775, 0.885, 0.935, 0.204, P >0.05. In CAD group, the p values of ESV, EDV, SV, EF were 0.864, 0.739, 0.538, 0.632, P >0.05.) And no significant differences were found between the healthy adults group and CAD group( p values of ESV, EDV, SV, EF were 0.235, 0.055, 0.063, 0.847, P >0.05 ). (2) Strong correlation between DSCT and echocardiography (r=0.70～0.87) was found for all parameters. Conclusions: (1) Excellent correlations between reconstruction of 2%, 5% and 10% of the R-R interval were shown for the assessment of LV function and LV volume. (2) DSCT angiography is noninvasive assessment of coronary tree, whereas the analysis of the left ventricular parameters provides additional information of cardiac function without further radiation exposure or scan time.