The Observation Of Macular Edema With Oct And Influence On Serum Level Of Vegf In Retinal Vein Occlusion Patients With Tcm Therapy Based On Stages

Objective:Observe macular edema of RVO patients and the RVO patients'VEGF level in blood serum treated by TCM pattern. Discuss the functional principal and find a sort of regular treatment method which would be used widely in future for bleeding ocular fundus diseases in TCM.Methods:Using the prospective, non-random and case seriois study, divided 30 cases (30 eyes) into bleeding stage, gore stage and dead-dry blood stage. Those cases were respectively treated with the home-made Chinese medicine (Puhuang Zhixuekoufuye, Danhong Huayukoufuye, Bujing Yishipian and Haikun Huayusanjiepian)in trial group.12 cases(12 eyes) were treated with Chinese patient medicine capsule Fufangxueshuantong in contral group. The clinical effect were observed in two groups principally by OCT and VEGF.Results:1. The trial group and contral group both could improve the visual acuity (p<0.01).The trial group improved more vision than contral group (p<0.05). Non-ischemic trial group improved more vision than contral group (p<0.05). And in ischemic, trial group is statictically remarkably superior to the contral group (p<0.01).2. Both groups could improve the shadow, line distortion and different sizes of panes, etc. of Asmeral test (p<0.01). The trial group improved more than contral group (p<0.05). There was no statistically different effect between groups in non-ischemic (p>0.05). And in ischemic, trial group is statictically remarkably superior to the contral group (p<0.01).3. Both groups can promote the absorption of retinal hemorrhage (p<0.01). The trial group was statistically remarkably superior to the contral group (p<0.01), both non-ischemic and ischemic.4. Both groups can relieve macular edema and the trial group was better than the contral group (p<0.01). In ischemic type, the trial group can relieve macular edema (p<0.05) while the contral group can not (p>0.05). The effection of trial group in fovea centralis area is better than outer macula area (p<0.05). Each area almost has the same effect in relieving edema in contral group (p>0.05). Eyesight and thickness of the retina in macular region has obvious correlation (p<0.01)5. The level of blood serum VEGF before treatment, ischemic is higher than non-ischemic (p<0.01). The level of blood serum VEGF after treatment, the trial group is remarkably lower than the contral group (p<0.01). In trial group, ischemic can increase the level (p<0.05) and non-ischemic unchanged(p>0.05). In contral group, ischemic and non-ischemic will increase the level (p<0.05)Conclusion:This study showed that OCT examination can be used as indicators of the efficacy of TCM treatment of RVO.The therapeutic effect is more predominant in TCM pattern treatment than in non-TCM pattern treatment, especially in non-ischemic pattern treatment. Listed details as follows:1. It could improve the symptoms and increase vision acuity, especially in non-ischemic.2. It could improve the abnormally situation of non-ischemic sufferers in Amsler test..3. It could improve bleeding absorption.4. It could improve relieving macular edema, especially in non-ischemic. And pattern treatment has more remarkable effection in fovea centralis areas than outer macula areas.5. It could make the level of blood serum VEGF stable in non-ischemic. Non-TCM pattern will increase the level.