Study On The Effects And Its Mechanism Of Traditional Chinese Medicine Of Bushenhuoxue On Lateral Geniculate Nucleus Injury In Rat Model Of Chronic Elevated Intraocular Pressure

Objective:To observe the effect traditional Chinese medicine(TCM) of BuShenHuoXue on the injury LGN rat model of chronic elevated intraocular pressure(EIOP), and preliminarily explore its mechanism.Methods:By unilaterally cauterizing 3 episcleral vessels, establish the rat model of chronic EIOP. Randomly divided into 3 groups:normal control group,model control group and treatment group. After given TCM drugs of BuShenHuoXue and normal saline for 8 weeks,killed the rats and taken out the brains. To observe the effection of BuShenHuoXue method on the EIOP rat model's intraocular pressure(IOP), Pathological changes of LGN and expression of brain-derived neurotrophin factor(BDNF).Results:Unilaterally cauterizing episcleral vessels increased IOP of the rat modle obviously(P<0.01).At the end of the experiment,the level of IOP was 2.5-3 times than Before modeling; the effects of BuShenHuoXue on the model LGN injured rat of chronic EIOP as follows:Slightly lower IOP;repaired injury LGN;improved the expression of BDNF of LGN on the EIOP rat model.Conclusion:This model is simple and stable, and moderately elevated IOP,which can last at least 2 months. TCM of BuShenHuoXue can protect the visual function on the rat model of chronic EIOP.The effects mainly effects as:Slightly lower IOP; repaired injury LGN;improved the expression of BDNF of LGN on the EIOP rat model.