The Effect Of Acupuncture And Drug Treatment On The Expression Of Bndf And Bcl-xl In The Retina Of Chronic Experimental High Intraocular Pressure Rabbit

Objective:To observe the protective effects of acupuncture and drug treatment on optic nerve of the rabbits model whose intraocular pressure was reduced to normal after chronic intraocular pressure elevated(IOP), and study the mechanism of it.Methods:Elevated intraocular pressure was gotten by injection of 0.3% carbomer into anterior chamber of albino rabbit.IOP was reduced to normal through conventional glaueomatous trabeculetomy after the intraocular pressure continuously for 4 weeks.Acupuncture,TQMMⅣand cerebroprotein hydrolysate injection treatment was used to treat the rabbits everyday in the treated group after the trabeculetomy for 1 months.The ultrastructure of retina and optic nerve was less damaged. To observe the affection on the expression level of Bcl-xl and BDNF in retinal.Results:Electron microseope result indicated that compared with experimental group optic nerve axons swelled relatively gentler, and the degree of damaged retina ganglion cells in treated group was lesser than that in experimental group(p<0.01).Expression level of Bcl-xl and BDNF in retinal was enhanced in treated group(p<0.01).Conclusion:Acupuncture and drug treatment can protect the optic nerve from elevated IOP, by alleviated the damages of the retinal and optic nerve axons ultrastructure induced by chronic ocular hypertension, and enhanced the expression level of Bcl-xl and BDNF in retina.