The Expression And Clinical Significance Of Vegf And Ln-r In The Ovarian Cancer

Objective:To explore the role and clinical significance of vascular endothelial growth factor(VEGF)) and lmainin recepetor (LN-R) in ovarian cancer.Methods:Using method of Immunohistochemical SP, the expression of VEGF and LN-R in 19 cases of normal ovarian tissues,23 cases of benign ovarian tumors and 42 cases of ovarian cancer were detected. Statistical analysis was performed with chi-square test and Sperman correlation.The relationship of their expression and pathological type, histological grade, FIGO stage, whether having metastasis were analysised.Results:1. The positive expression of VEGF in normal ovarian tissues and benign ovarian tumors and ovarian cance were 10.5%,43.4% and 73.8%,respectively.The positive expression rate of VEGF was significantly different in normal ovarian tissue and benign ovarian tumor tissue (P<0.05) and also was significantly different in benign ovarian tumor and ovarian cancer.(P<0.05)2. The positive expression rate of VEGF in ovarian serous adenocarcinoma was 76%,that in other ovarian cancers was 70.6%. The difference of VEGF positive expression rate of the two groups was unsignificant (χ2=0.153, P>0.05); The positive expression rate of VEGF in the poorly differentiated group (90.9%) was significantly higher than that in the high differentiated group (55%) (χ2=6.98, P<0.05);The rate of positive expression of VEGF in StageⅢ-Ⅳ(86.9%) was significantly higher than that in the stageⅠ-Ⅱ(57.8%) (χ2=4.54, P<0.05); In the ovarian cancer tissues with lymph nodes or omentum metastasis,the VEGF positive expression rate was 86.4%, significantly higher than that without metastasis (55%)(χ=5.05, P<0.05)3. LN-R did not express in normal ovarian tissue,LN-R expressed in benign ovarian tumors with low level (4.3%),with high levels of expression in ovarian cancer (76.2%). The positive expression rate of LN-R was significantly different between benign ovarian tumor and ovarian cancer.(P<0.05)4. The positive expression rate of LN-R in ovarian serous adenocarcinoma was 76%, that in other ovarican cancer was 76.5%. LN-R positive expression rate of the two groups had no significant difference (χ2=0.001, P>0.05); The positive expression rate of LN-R in the poorly differentiated group (90.9%)was significantly higher than that in the high differentiated group(60%) (χ2=5.51, P<0.05); The positive expression of LN-R in stageⅢ-Ⅳ(91.3%) was significantly higher than that in the stageⅠ-Ⅱ(57.8%) (χ2 =6.40, P<0.05); The positive expression rate of LN-R in ovarian cancer with lymph nodes or omentum metastasis(81.8%) was significantly higher than that without lymph nodes or omentum metastasis (50%)(χ2=4.77, P<0.05) 5.VEGF and LN-R show some positive correlation in the occurrence and development of ovarian cancer. (P<0.05)Conclusions:1. VEGF and LN-R play a role in the occurrence and development of ovanan cancer.2. The positive expression of VEGF and LN-R has relationship with clinical stage and histological grading, lymph nodes or omentum metastasis, and has no relationship with pathological type; which indicated that VEGF and LN-R could predict prognostics of ovarian cancer.3. VEGF and LN-R show some correlation in the occurrence and development of ovarian cancer, which indicated that they cooperated in the occurrence and development of ovarian cancer.